Categories: Weight loss

Ozempic for weight loss

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Ozempic to lose weight? Yes, Ozempic can be used for weight loss. Ozempic is a drug that regulates, maintains, and improves blood sugar in type 2 diabetes and may also promote weight loss.

Ozempic has been proven to significantly lower blood sugar and A1C. The Ozempic website refers to research comparing Ozempic and similar drugs.Ozempic for weight loss


How Ozempic Works

The active ingredient in Ozempic is semaglutide. It is a glucagon-1-like peptide (GLP-1) receptor agonist. Like this hormone, semaglutide regulates insulin secretion. More specifically, it increases the release of insulin, which has a hypoglycemic effect (lowering blood sugar levels).

This drug therefore allows sugar to travel from the blood to the cells more easily, where it can be used to provide energy. Ideal for type 2 diabetics who have rebellious blood sugar!

Ozempic for weight loss compared to other popular drugs

Ozempic vs Trulicity for weight loss

A study comparing Ozempic and Trulicity clearly showed that people on Ozempic lost more weight than those on Trulicity. The study lasted 40 weeks with 1201 adults currently taking metformin and diagnosed with type 2 diabetes. The study directly compared Ozempic 0.5mg vs Trulicity 0.75mg and Ozempic 1mg vs Trulicity 1 .5mg

Ozempic vs Bydureon for weight loss

A study between Ozempic and Bydureon concluded that people on Ozempic lost more weight than those on Ozempic Bydureon. This 56-week study involved 813 people with type 2 diabetes who have been put on Ozempic 1mg or Bydureon 2mg with metformin and sulfonylurea or just metformin. Weight loss with Ozempic was about 10 pounds while on Bydureon was 4 Pounds.


However, some people have gained weight.

Ozempic vs Januvia for weight loss

A 56-week study comparing the effects of Ozempic and Januvia suggested that people taking Ozempic lost more weight than those taking Januvia. The study involved 1231 people with type 2 diabetes and Ozempic or Januvia were added to diabetic pills.

Weight loss with Ozempic 1mg, Ozempic 0.5mg, and Januvia was 12lbs, 9lbs, and 3lbs respectively.

Ozempic vs Lantus for weight loss

A 56-week study comparing the effect of Ozempic and Lantus suggested that people taking Ozempic lost more weight than those taking Januvia. The study involved 1089 people with type 2 diabetes and Ozempic or Lantus were added to diabetic pills.

Weight loss with Ozempic 1mg and Ozempic 0.5mg was 10lbs and 7lbs respectively. While the people on Lantus gained two pounds in weight.

Ozempic Weight Loss Dosage

Note: For use in addition to diet and exercise in patients with a BMI ≥ 30 kg/m2, or in patients with a BMI ≥27 kg/m2et≥1 weight-related comorbidity (peg, hypertension, dyslipidemia).


SUB-Q: Initiate and adjust dose using the following schedule: In patients who cannot tolerate a dose increase, consider delaying the increase for an additional 4 weeks:

Week 1 to week 4:0.25 mg once a week.

Week 5 to week 8:0.5 mg once a week.

Week 9 to week 12:1 mg once a week.

Week 13 to week 16:1,7 mg Une fois par semaine.

Week 17 and beyond (maintenance dose):2.4 mg once weekly; if not tolerated, may temporarily decrease dose to 1.7 mg once weekly for up to 4 additional weeks, then increase to 2.4 mg once weekly.


Note: According to the manufacturer, treatment should be discontinued in patients who cannot tolerate the 2.4 mg/week dose; however, some experts will continue a patient on the maximum tolerated dose (even if <2.4 mg/week) if the weight loss goal is achieved with that dose (Perreault 2021; manufacturer’s labeling). Consider discontinuation if at least 5% of baseline body weight loss has not been achieved within 3 months (ADA 2021).

Missed Dose: The missed dose should be administered as soon as possible within 5 days; resume the usual schedule thereafter.

If > 5 days have passed, skip the missed dose and resume dosing at the next scheduled weekly dose. If more than 2 consecutive doses are missed, resume dosing as scheduled; alternatively, may restart the dose adjustment program.

What are the possible side effects of this medication?

Many medications can cause side effects. A side effect is an adverse response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medication have reported the following side effects. Many of these side effects are manageable and a few may go away on their own over time.


Consult your doctor if you experience these side effects and if they are severe or bothersome. Your pharmacist may be able to advise you on what to do if these side effects appear:

•a decrease in appetite;


• a change in the taste of solid or liquid foods;






•flatulence or belching;

•mild abdominal pain or bloating;


•redness, swelling or itching at the injection site; and



Is Ozempic covered by RAMQ?

Yes! Ozempic is listed on the list of medications in the province of Quebec that are covered by theRégie de l’assurance maladie du Québec(RAMQ). However, only people who have been diagnosed with type 2 diabetes can benefit from it. Ozempic can also be prescribed for other therapeutic indications by a physician who must, however, complete a payment authorization request that will be reviewed by the RAMQ.

If you have private insurance instead, know that many plans reimburse this drug.

Did you know that…

Ozempic comes as a solution in pre-filled, disposable pens? Injections are given under the skin of the thigh, abdomen or upper arm once a week.

Who takes Ozempic?

While it is true that overweight adults without diabetes can also lose significant weight with Ozempic, especially when combined with a lifestyle change, semaglutide is not reserved only for people suffering from type 2 diabetes. Perhaps it will soon be offered as an alternative to promote weight loss in certain individuals who do not suffer from diabetes? This is a case to follow.


At this time, Ozempic is therefore only recommended for people with type 2 diabetes. It is often prescribed when other measures such as exercise, healthy eating and taking other medications are not effective enough. to improve blood sugar levels in these people.

Saxenda for weight loss, what do we think?

Ozempic’s main competitor in weight-loss drugs is liraglutide, known as Saxenda. However, it is less convenient than its competitor since it must be administered daily.

A study 4 comparing the two competitors was carried out on a total of 957 people without diabetes, but suffering from obesity. Some received varying doses of daily injections of Saxenda, others received Ozempic and others a placebo. After one year, 65% of participants receiving the highest dose of Ozempic would have lost at least 10% of their weight compared to 34% of participants who received Saxenda. Impressive, isn’t it?

In summary!

Although Ozempic appears to be the leading weight-loss drug, more studies are needed before recommending it to the general population. Also, remember that this is not a miracle drug! Changes in lifestyle, diet and physical activity must be combined with taking this medication to see real changes! And watch out for the side effects of Ozempic!

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