Health
Contraindications and side effects of Bupropion
Discover the contraindications and side effects of Bupropion.
This psychotropic drug is used both to treat depressive symptoms and in tobacco addiction.
A drug belonging to the IRND.
Tobacco is one of the substances with psychoactive effects that have been used the most legally since its discovery.
Even though today smoking is prohibited in establishments and closed public spaces and its price has risen based on taxes, millions of people still have the habit of smoking.
But many of these people, at some point, need to stop. Although it is possible to do it voluntarily, in some cases they may require psychological and even pharmacological help.
In the latter case, one of the existing drugs used to quit smoking is bupropion, a drug that originated as an antidepressant.
What is bupropion?
Bupropion is a well-known antidepressant drug, although more than in its application for depression it is more common and distinctive due to its efficacy in the treatment of tobacco addiction.
In this sense, it is a treatment that does not include nicotine and that is recommended together with some type of therapy or psychological treatment.
This shows that psychotropic drugs are not designed following a plan from scratch, but rather that there is a certain process of trial and error in their development, and that sometimes there are benefits for the drug that were not even taken into account at first.
Bupropion is a specific dopamine and norepinephrine reuptake inhibitor, or NRDI , that works by increasing the levels of these neurotransmitters in the brain.
Compared with other drugs in the group of antidepressants, bupropion has the advantage of not causing sexual dysfunctions, although, on the other hand, its effectiveness alone seems less compared to other drugs on the market.
Thus, bupropion is an example that molecules related to other substances used for a certain class of disorder may be more useful in different health conditions, no matter how similar their structure is.
Mechanism of action
The function of bupropion and its mechanism of action is based on its role as a selective inhibitor of dopamine and norepinephrine reuptake.
This implies that bupropion works by preventing these two transmitters (associated with gratification and energy) from being re-uploaded by the presynaptic neuron, in such a way that they are available to postsynaptic neurons for a longer time.
Furthermore, it appears to stimulate the secretion of these neurotransmitters.
Thus, dopamine and norepinephrine levels and their transport increase at the brain level, something that can alter the mood.
Likewise, it has also been observed that it has an effect at the level of acetylcholine, binding to nicotinic receptors and exerting a non-competitive antagonistic effect.
Although there is no total security for this, this element is one of the possible explanations for its role in smoking cessation.
However, it must be taken into account that the exact way in which the mechanism of action of bupropion and psychotropic drugs in general works is still unknown.
Its use does not guarantee that it will work to alleviate the symptoms of the disorder to be treated, and its efficacy is only slightly better than that of a placebo.
That does not mean that in many cases it is very useful, simply that the percentage of patients who try this treatment and do not obtain any benefit is relatively high.
Indications: uses in disorders
Bupropion is a drug that has had various uses throughout its history. Although it was born as an antidepressant and today it is still used to treat this condition both as monotherapy (single therapy) and combined therapy (more common, to enhance some specific antidepressants when first-line drugs are not effective), the truth is is that by itself it is generally considered less effective than other antidepressants.
Where this drug stands out and has the greatest use is in smoking cessation, being effective in reducing the consumption habit and the urge to smoke.
In this sense, its mechanism of action seems to contribute to stopping craving (possibly due, on the one hand, to its antagonism of nicotinic receptors and its interaction with brain dopamine, although the exact mechanism is not fully known).
Another disorder in which it is used is seasonal affective disorder, in which depressive episodes appear associated with certain times of the year.
In addition to the above, it has sometimes been used in the treatment of bipolar disorder, especially during the depressive episodes that can occur in this disorder (although this use requires caution since there is a risk of turning the disorder into a manic crisis).
Also in ADHD. But in any case, further research is required and possible risks must be taken into account.
Side effects of Bupropion
Bupropion is a drug that is very useful in smoking cessation and is used in cases of depression, but as with other drugs, its clinical utility is not free of risks and possible side effects.
This occurs because the active substance in bupropion affects many areas of the body, not just the areas that could produce an improvement in symptoms.
This unwanted interaction generates a chain reaction of consequences to some extent unpredictable, which can lead to new health disorders (although they tend to disappear as the substance leaves the body). Therefore, its use should always be supervised and indicated by doctors.
In this sense, among the main side effects of bupropion, we can find the cause of insomnia (being one of the most frequent), dry mouth and dizziness, headaches, nausea, constipation, rapid heartbeat, tremors, skin rashes, agitation, and nervousness. It can also cause a decrease in appetite.
In more serious cases it can generate seizures (this being one of the most well-known serious risks), arrhythmias, hallucinations, panic or difficulties in breathing or feeding, or inflammations being necessary to see a doctor. In some cases, it can cause irritability, hostility, depression, suicidal thoughts.
Contraindications of Bupropion
In addition to these side effects, this drug is contraindicated in some sections of the population.
People who are allergic to it or any of its components (something obvious on the other hand), those who consume certain medications (especially MAOS), dependence on substances other than tobacco (such as alcohol, drugs, and pharmaceuticals), and those who suffer from epilepsy, brain tumors and anorexia nervosa or bulimia (since it reduces the appetite).
It is also not recommended, although it can sometimes be used if the benefits are considered greater than the risks, in cases of people with kidney or liver failure, head trauma, insomnia, or the use of other medications that may interact with bupropion.
Diabetics, alcoholics, hypertensive or people with psychiatric disorders (since it can contribute to the appearance of mania in bipolar or psychotic crisis in schizophrenia, among others) also have it contraindicated (or at least the treatment should be done with a high level of control of the patient’s condition and the doses administered) due to the risk of seizures and other side effects.
Finally, it is not recommended for pregnant and lactating women either
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Health
Benefits of coconut water in pregnancy
Discover the benefits of coconut water in pregnancy.
Coconut water is a clear, sweet, energizing isotonic drink that helps your body replenish lost fluids. Also known as Nariyal Pani and Elaneer in India, it is known for its versatility and countless nutritional benefits.
IS IT SAFE TO CONSUME COCONUT WATER DURING PREGNANCY?
Yes, it is safe to drink coconut water, but in moderation, as it contains natural vitamins and minerals.
Having coconut water in the first trimester helps curb dehydration resulting from morning sickness. It’s also good for heartburn and constipation, common symptoms of pregnancy.
You can drink coconut water at any time, but the best time is early in the morning. It is healthier, as the electrolytes and nutrients can be easily absorbed when the stomach is empty.
The nutritional benefits present in a cup of coconut water include:
•Calories 46
•Sodium 252mg
•600mg potassium
•Carbs 8.9 grams
•Dietary fiber 2.6 grams
•Sugars 6.26 grams
•Calcium 6%
Benefits of coconut water in pregnancy
You can reap its benefits only when you consume fresh water, as it begins to ferment when left open and exposed to air.
1. NATURAL DIURETIC:
During pregnancy, uric acid levels should be normal in your body system. Coconut water is a diuretic and increases the need to urinate due to the presence of potassium, magnesium, and minerals.
They help eliminate toxins and cleanse the urinary tract. Thus, it improves kidney function and prevents kidney stones and infections. It also prevents urinary tract infections, which reduces the chances of preterm labor.
2. OFFERS ESSENTIAL ELECTROLYTES:
The need for electrolytes increases during pregnancy because conditions like morning sickness, nausea, and diarrhea dehydrate the body. Coconut water supplies all five essential electrolytes: minerals, sodium, calcium, potassium, and phosphorus, which calm the body and provide energy.
These electrolytes transmit electrical charges in your body and aid in muscle function. They also help maintain your body’s pH levels and control blood pressure levels. It is known to have cooling properties, which prevent conditions such as bilious fever and vomiting.
3. RELIEVES HEARTBURN AND CONSTIPATION:
Hormonal changes during pregnancy lead to various problems like heartburn, constipation, and indigestion. The rich content of dietary fiber in coconut water strengthens the digestive system, improves digestion, regulates pH levels, and prevents constipation.
Ayurveda considers young coconut water to be an excellent laxative. Improves metabolism and detoxifies the body. Coconut water is a natural acid neutralizer and thus prevents heartburn.
4. TREAT INFECTIONS:
Coconut water is rich in vitamins, essential minerals, and antioxidants, which boost your immune levels, providing resistance to infections. It contains lauric acid, a medium-chain fatty acid responsible for the production of a powerful antiviral monolaurin, Michelle-Lee Young writes in the book “Two Trees and Twelve Fruits That Will Change Your Life Forever.” Lauric is a disease-fighting acid that kills harmful bacteria and infections like the flu, and HIV, and retains good bacteria.
5. IMPROVES HEART HEALTH:
Low electrolyte level increases blood pressure. Drinking coconut water improves levels of potassium, magnesium, and lauric acid, which help regulate blood pressure. Improves good cholesterol and fights bad cholesterol.
The vitamins, essential proteins, and electrolytes in coconut water control sugar levels, and blood pressure levels, and improve circulation. A glass of coconut water every day is particularly helpful in the last trimester when there is increasing stress from labor that can increase your blood pressure.
6. MAINTAINS A HEALTHY WEIGHT:
Coconut water is fat-free and low in calories. As pregnancy adds extra weight to your body, coconut water prevents fat accumulation by removing bad cholesterol. It is an excellent replacement for sugary drinks and helps both the mother and the growing fetus to be healthy and fit.
7. NATURAL DRINK:
Coconut water is a tasty natural drink. It has no artificial flavors or harmful components. It is safe for you and your growing fetus as none of its components affect your health.
8. ENERGIZE AFTER TRAINING:
Coconut water is a natural isotonic drink, which helps you gain energy when suffering from dehydration, fatigue, and exhaustion. It is a great revitalizer
. If you exercise regularly to stay fit and strengthen your pelvic muscles, you can opt for coconut water as an energy drink. Hydration also improves skin elasticity, limiting the stretch marks that develop during pregnancy.
9. LOW SUGAR CONTENT:
Excessive sugar intake can lead to an increase in overall blood sugar levels. Coconut water has less sugar than other sports and energy drinks. You won’t gain pregnancy weight, and a diet low in simple sugars will reduce your risk of getting gestational diabetes.
10. ACCELERATES THE GROWTH OF THE FETUS:
Coconut water offers all the nutrients to the mother, essential to maintain and improve her health. Thus, it improves the health, growth, and proper nutrition of the unborn baby.
11. IMPROVES AMNIOTIC FLUID LEVELS:
Drinking coconut water improves the overall health and environment of your growing fetus. Coconut water taken especially in the third trimester increases amniotic fluid levels and improves blood volume and circulation.
ARE THERE ANY SIDE EFFECTS OF COCONUT WATER DURING PREGNANCY?
There is no evidence that coconut water has adverse effects on pregnancy. Like any other fruit or vegetable juice, it also appears to be safe. But there are two things to keep in mind:
•Coconut milk contains sodium, which may not be the right choice for pregnant women with preeclampsia.
•Ripe coconut water can cause constipation.
HOW MUCH COCONUT WATER CAN A PREGNANT WOMAN HAVE?
Moderation is always the key when it comes to eating a healthy diet. You can drink up to a glass of coconut water a day.
Consume the water soon after opening, as a fresh one will contain rich nutrients. Use a clean straw or pour it into a glass and drink.
It is always good to prefer natural coconut water to canned or bottled.
Do not consume coconut water if you react or do not like its taste.
HOW TO SELECT THE CORRECT COCONUT?
To enjoy the various benefits of coconut water, you need to know how to select them properly. These tips can help you buy fresh and tender coconut.
A fresh coconut will be light and sweet and will not contain coconut meat, the white, meaty, tender substance. A ripe or stale one will taste sour.
Selection: Choose medium-sized, clean, green walnuts, as they contain large amounts of water. Don’t choose coconuts that have hard brown shells and gray patches as they indicate ripe nuts.
Water: Shake the coconut vigorously near your ear to check for water. Select the ones that make a good splashing sound. A fresh coconut will contain almost a cup of water.
If you want to store coconuts at home, keep them in a cool place.
BENEFITS OF COCONUT MEAT DURING PREGNANCY:
1. GENERATION OF BREAST MILK:
Regular consumption of coconut meat during pregnancy improves the supply of breast milk after childbirth. Your baby will receive nutritious and rich breast milk. Also, coconut oil helps in the generation of breast milk.
It is also good during the lactation phase as it contains lauric and capric acids. These acids have antiviral, antibacterial, and parasiticidal effects, which protect the baby from diseases.
2. IMPROVES BLOOD CIRCULATION:
Blood volume doubles during pregnancy, causing swelling of the feet and legs. Poor blood circulation aggravates the condition. Coconut consumption improves blood circulation and prevents swelling and pain in the legs.
3. HELPS DIGESTION:
Consuming coconut meat and water prevents constipation as tender coconut meat acts as an excellent laxative. It is one of the best benefits of consuming a coconut in any form during pregnancy.
4. BETTER SLEEP:
Having coconut in combination with poppy seeds and ghee will improve your sleep cycle.
5. INCREASES METABOLISM:
When the coconut is mixed with spices, it helps boost metabolic activities in pregnant women.
COCONUT MILK DURING PREGNANCY:
Coconut milk is a thick, milky liquid obtained by grinding grated coconut meat. It is also an essential ingredient in many foods, especially Southeast Asian dishes.
Coconut can be consumed in any form due to its amazing health benefits. Coconut milk helps increase body fuel. It is completely safe to drink unless you are allergic to it.
BENEFITS OF COCONUT MILK DURING PREGNANCY:
1. ENHANCE IMMUNITY:
Coconut milk contains lauric acid, which is an antibacterial and antiviral fat, useful for pregnant women. This type of fat helps improve the immune system, according to the book “Coconut Oil and the Immune System” by Sherri Neal. The long-chain fatty acids straighten the blood vessels and reduce any blockages in the heart, thus improving the condition of the heart as well.
2. OTHER BENEFITS INCLUDE:
•It contains good amounts of iron, which can treat anemia.
•Improves digestive problems.
•It offers relaxation to the muscles and the nervous system.
•Controls blood sugar levels and blood pressure
•Relieves joint pain and scratches
•Makes your body fit and helps you lose weight
HOW TO PREPARE FRESH COCONUT MILK?
It is advisable to make coconut milk at home instead of opting for a packaged one.
Grate a whole coconut and add a cup and a half of hot water.
Let the mixture cool to room temperature.
Once the mixture cools down, strain to get the milk.
Coconut milk taken directly from fresh coconuts will contain approximately 450 calories and 50 g of fat. A cup of coconut milk (approximately 240 g) has the following nutritional values:
•Calories 550
•Fats 50.2gm (all types of fats)
•Cholesterol 0
•Sodium 40gm
•Carbohydrates 14gm (in 250gm of milk)
•Proteins 6gm
•Vitamin C 11%
•Iron 22%
•Calcium 4%
IS CANNED COCONUT MILK GOOD DURING PREGNANCY?
It’s safe to have canned coconut milk during pregnancy, but you need to make sure the can isn’t corroded, rusted, expired, or stored at dangerous temperatures.
Coconut milk contains considerable amounts of saturated fat, that is, 3 g in a tablespoon. Eating too much-saturated fat will increase the levels of good and bad cholesterol in the body. In the case of canned milk, you must take into account your level of consumption, since you should not exceed your daily requirement.
In addition to the above, other reasons why you may not choose canned coconut milk are:
1. BISPHENOL A (BPA):
It is a chemical that is typically used in the lining of cans used for packaged foods. This BPA can gradually leach into acidic, fatty, or salty foods like coconut milk, vegetables, tomatoes, and soups. One study claims that there is a relationship between high levels of BPA in mothers and neurobehavioral problems in babies.
2. GUAR GUM:
Guar gum is an additive present in canned coconut milk. It is a galactomannan, a polysaccharide, and is primarily a ground endosperm of guar beans.
There have been complaints such as severe abdominal cramps, indigestion, flatulence, and diarrhea, as beans are difficult to digest. In a clinical experiment, patients with intestinal problems showed improvement when they stopped using canned coconut milk in their diet.
3. FRUCTOSE MALABSORPTION:
It is a digestive disease characterized by impaired transport of fructose (a simple sugar found in fruits, vegetables, and honey) through the small intestine. Increased fructose levels in the gut cause bacterial overgrowth.
Therefore, it reduces the absorption of water in the intestine. Pregnant women with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are highly affected by fructose malabsorption.
According to nutrition data, coconut milk contains sugar, including fructose. Therefore, it should be avoided by those affected by IBD and IBS disorders.
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