Connect with us

Health

Contraindications and side effects of Trazodone

Published

on

trazodone contraindications

Discover the Contraindications and side effects of Trazodone.

Trazodone is used in a wide variety of disorders, although it is an antidepressant.

Being depression one of the most prevalent mental disorders worldwide and one of the major causes of disability, its treatment is a matter that the scientific community has taken into account for many years.

The suffering it generates requires sometimes immediate attention since it is one of the disorders with the highest risk of suicide and that generates the most pain both for the person and for those around him.

The treatment of depression is carried out from different areas, one of them being psychopharmacology.

Advertisements

One of the drugs used in the treatment of depression is trazodone, which we are going to talk about in this article.

Trazodone: what type of substance is it?

Trazodone is a psychotropic drug classified within antidepressants, substances that generate a neurochemical change at the brain level, causing alterations in the levels of certain neurotransmitters, specifically serotonin.

Among antidepressants, it is part and is the main representative of the group of serotonin-2A antagonists and reuptake inhibitors or SARIs, a type of atypical antidepressant.

This drug was designed in Italy in 1966 under the assumption that depression could be based on the existence of low thresholds regarding the perception of pain and suffering, being the product of the lack of integration of aversive experiences.

Trazodone has proven to be an efficient and effective drug in the treatment of depression, reducing passivity and inactivity, as well as the discomfort and suffering associated with said ailment, and facilitating an increase in mood.

However, in addition to this, it also has an anxiolytic and tranquilizing action.

This substance is considered a second-generation antidepressant, along with specific serotonin reuptake inhibitors (SSRIs), with which it shares part of its mechanism of action, and different dual antidepressants.

Trazodone is sometimes considered to be dual as it has two different effects, although they focus on the same neurotransmission system, compared to the rest, and in addition to an antidepressant effect, it also has calming effects.

How does it work? Mechanism of action of the drug

As we have indicated previously, trazodone is classified as SARI, having a somewhat special mechanism of action among the rest of antidepressants.

Trazodone acts at the serotonergic system level (like most antidepressants) in two specific ways.

In the first place, this substance produces a blockage of brain serotonin reuptake, in such a way that said neurotransmitter remains in the synaptic space for a longer time.

This supposes that it has an agonist effect on the synthesis and maintenance of serotonin at the brain level, it increases its levels (which are decreased during the depression and this is something that correlates with the decrease in the mood).

The aforementioned mechanism of action is the one used by SSRIs, which is why these and trazodone are related and sometimes the latter is included among the first.

However, trazodone has a second effect that differentiates it from other drugs, and that seems contrary to the previous mechanism of action.

And it is also that it acts as an antagonist of serotonin 5-HT2A receptors, preventing or hindering these receptors from being activated.

This second aspect is what makes trazodone have a slightly different profile and effects than other antidepressants.

Regarding its interaction with other neurotransmitter systems, it does not present great anticholinergic effects, something that has made this drug a better option than tricyclics (although the doses must also be regulated) in patients with cerebrovascular and cardiac pathology and dementias.

However, it must be taken into account that it can generate arrhythmias.

Advertisements

It also has a minor effect on the adrenergic (blocking some receptors) and histaminergic systems, something that can lead to the generation of side effects.

Main indications

The main indication for trazodone is obviously, as an antidepressant that it is, major depression. Its effectiveness is also high in those depressions that appear together with anxiety symptoms.

Its clinical utility has also been observed in other disorders in which there are components of anxiety or that are based on it, such as generalized anxiety disorder, Obsessive-Compulsive Disorder, or bulimia.

In addition to this, it has also been observed to be useful for the treatment of substance addictions, being a good alternative for patients with withdrawal syndrome to benzodiazepines, and in the treatment of alcoholism (including the presence of delirium tremens).

Another of its indications is insomnia, which is effectively reduced by increasing sleep time without greatly affecting the deep sleep phase.

Although in general, most antidepressants can have the presence of erectile dysfunction or ejaculation problems as a side effect, this effect does not usually occur in trazodone, which seems to generate an increase in libido and is even used as a treatment indicated in erectile dysfunction.

Finally, trazodone has been applied (largely for its relaxing properties) in some cases of schizophrenia, motor problems such as Gilles de la Tourette syndrome, the presence of manic episodes in bipolar disorder, and the behavioral disorders of Alzheimer’s. although a greater amount of study is required regarding the latter.

On a medical level, it has also been used as a sedative in HIV-infected patients and diabetic neuropathies, as well as in other disorders that cause pain such as fibromyalgia. It has a very slight effect at the level of muscle relaxant.

Side effects and contraindications

Trazodone is a very useful drug that has been used in multiple pathologies and disorders, both mental and medical.

However, it can have undesirable consequences in the form of side effects and is even contraindicated in some situations and pathologies.

Secondary symptoms, sedation, and fatigue, the presence of headaches, nausea, and vomiting, gastric disturbances (diarrhea or constipation), appetite disturbances, sweating, tremors (which may lead to seizures in some cases), are common. ringing, numbness, and vision problems.

In some cases, it can also cause chest and muscle pain, altered consciousness, breathing problems, and arrhythmias. Like other antidepressants, trazodone can also contribute to the genesis of suicidal ideation in the first moments of use.

Although, unlike other antidepressants, it does not seem to generate contributes to improving cases of erectile dysfunction or ejaculatory problems, the use of trazodone has been observed and associated with the appearance of priapism, erections that do not disappear on their own. alone and that cause pain to those who suffer from them (which may require urgent and even surgical treatment).

Although it is sometimes used in dementias and has a lower risk than tricyclics of generating heart problems, it requires a high degree of caution in its use and dosage carefully prescribed by the doctor, since it can generate arrhythmias.

It is contraindicated in patients who have just suffered a heart attack, as well as in those with liver or kidney disease.

Caution should be exercised in subjects with bipolarity because if the medication is not regulated, the consumption of trazodone can cause a shift from depressive to manic phase.

It is also contraindicated in people who have suffered from priapism or have Peyronie’s disease.

Advertisements

Finally, it must be taken into account that trazodone can be excreted in breast milk and transmitted through the placenta so that pregnant and lactating women have contraindicated its use.

Health

Relieve Arthritis Pain With Professional Services – A Comprehensive Guide

Published

on

By

Arthritis pain services Jersey City, NJ

Most of our joints are surrounded by a fluid that lubricates and nourishes them (think oil for a squeaky hinge). This fluid is protected in a capsule by ligaments and tendons.

Various treatment options are available for arthritis, including medication, physical therapy, and making specific lifestyle changes. These treatments can reduce pain, help people stay active, and, in some cases, slow joint damage.

Physical Therapy

Many people think of physical therapy in connection with an injury or surgery, but it’s also a valuable way to relieve arthritis pain. Arthritis pain services Jersey City, NJ can help you move more efficiently, use techniques to ease your pain, and learn how to modify your daily routine to minimize joint stress.

PT can include manual manipulation of the affected joints, massage, exercises to strengthen the muscles around your joints, and treatments based on heat, cold, electrical stimulation, or ultrasound. Your therapist may also suggest ergonomic devices to make your daily activities easier or recommend a special brace or other support device.

Studies show that PT reduces arthritis symptoms, improves mobility, and enhances the quality of life. It’s a vital part of an arthritis treatment plan and may even help you avoid surgery in some cases. Most insurance and medicare cover at least part of the cost. Generally, a treatment plan lasts about four to six weeks.

Medications

There’s no cure for arthritis, but your provider can help you manage it so you can spend more time doing things you enjoy and less time feeling stiff and sore.

Over-the-counter (OTC) pain medications like acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs — including ibuprofen (Advil, Motrin), naproxen (Aleve), and diclofenac (Cambia, Cataflam, Voltaren) — work by blocking the enzyme cyclooxygenase in your body that makes prostaglandins substances that cause pain, swelling, and inflammation.

Some people also use glucosamine and chondroitin sulfate, supplements that are thought to help keep cartilage healthy in your joints. Your doctor can advise you on the best ones for you.

Lifestyle Modifications

While arthritis is often a result of overuse or aging, it can also be caused by autoimmune diseases like rheumatoid arthritis (RA). These conditions are much more severe and can lead to permanent joint damage and disability.

Aside from medications, lifestyle changes can help reduce pain and stiffness. Regular exercise, walking, swimming, bike riding, and stretching or yoga can improve flexibility, support joints, and strengthen muscles. A light massage, provided the therapist knows which joints are affected by your condition, can increase blood flow and warm up muscles, temporarily relieving pain.

For painful knees and ankles, inserts or braces can support the joints and lower pressure on them. Corticosteroid injections are powerful anti-inflammatory medications injected directly into the affected joint — and can decrease swelling and relieve pain for three to six months. Hyaluronic acid injections given in a series of shots to replace the fluid lost with osteoarthritis can alleviate pain for a similar period.

Support Groups

In addition to a doctor’s treatment plan, it is also essential for individuals with arthritis to make lifestyle changes. These may include regular exercises (walking, swimming, or bike riding) that can reduce pain and improve function in adults with arthritis and self-management education workshops that teach people how to cope with their symptoms and manage their arthritis.

Arthritis support groups are an excellent way to find emotional support from people who understand what you are going through. Your doctor’s office or local hospital can provide information about groups that meet in your area. The Arthritis Foundation offers online forums and chat groups for people with arthritis to connect. Several studies have found that attending a rheumatoid arthritis support group significantly improves the quality of life for participants. However, it is essential to note that participation in a support group should not be seen as a replacement for medication or standard care from a health professional.

Continue Reading

Health

How Blair Batson Children’s Hospital Supports Families of Hospitalized Children

Published

on

By

Blair Batson Children's Hospital Greenwood MS

Blair Batson Children’s Hospital stands as a beacon of hope and healing for families facing the challenges of pediatric illness and injury. Beyond providing exceptional medical care to young patients, the hospital recognizes the importance of supporting families during their difficult journey. 

Family-Centered Care Approach

At Blair Batson Children’s Hospital, family-centered care is more than a philosophy; it’s a guiding principle woven into every aspect of patient care. The hospital ensures that families are actively involved in decision-making, treatment plans, and care routines. From open communication with healthcare providers to family-friendly amenities and accommodations, Blair Batson Children’s Hospital Greenwood MS creates a supportive environment where families feel valued, respected, and empowered. Furthermore, Blair Batson Children’s Hospital recognizes the unique expertise that families bring to their child’s care journey and respects their role as essential partners in the healthcare team. By fostering collaboration and mutual respect between families and healthcare providers, the hospital cultivates a culture of trust and partnership that enhances pediatric patients’ overall quality of care.

Comfortable Accommodations

Recognizing the importance of a supportive environment for families, Blair Batson Children’s Hospital offers comfortable accommodations and amenities to ensure their well-being during their stay. Family lounges, sleeping accommodations, and shower facilities provide respite and comfort to families needing extended hospital stays. Additionally, the hospital offers dining options, laundry facilities, and other conveniences to alleviate the stress of being away from home. Moreover, Blair Batson Children’s Hospital understands that the well-being of families extends beyond physical comfort and thus offers emotional support services and recreational activities to promote relaxation and resilience during challenging times. By creating a nurturing environment that addresses practical and emotional needs, the hospital strives to ease the burden on families and facilitate comfort and reassurance throughout their stay.

Emotional Support Services

Coping with a child’s illness or injury can take a toll on families emotionally and psychologically. Blair Batson Children’s Hospital offers various emotional support services, including counseling, support groups, and therapeutic activities, to help families navigate their feelings and build resilience. Trained social workers, child life specialists, and spiritual care providers offer compassionate guidance and resources to families facing difficult circumstances.

Educational Resources

Understanding the medical condition and treatment options is crucial for families to make informed decisions and actively participate in their child’s care. Blair Batson Children’s Hospital provides educational resources, workshops, and informational materials to help families understand their child’s diagnosis, treatment plan, and prognosis. By empowering families with knowledge, the hospital enables them to advocate effectively for their child’s needs and collaborate with healthcare providers.

Community Support Programs

Beyond the hospital’s walls, Blair Batson Children’s Hospital extends its support to families through community outreach programs and partnerships. These programs offer financial assistance, transportation services, and access to local resources to help families navigate practical challenges related to their child’s illness or injury. By leveraging community support networks, the hospital ensures that families receive comprehensive care and support throughout their journey.

Continue Reading

Health

Benefits of portobello mushrooms and side effects

Published

on

By

portobello mushrooms health benefits

Table of Contents

Continue Reading

Trending