Categories: Side effects

Contraindications and side effects of Clexane

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Discover the Contraindications and side effects of Clexane.

This anticoagulant drug is especially used to prevent blood circulation problems.

A drug against diseases of the blood circulation.

Cardiovascular problems are probably together with dementias and cancer some of those that cause the greatest concern to the majority of the population, given the importance for our survival of the fact that the blood circulates normally through our body and that the heart keeps pumping it in the normal way.Contraindications and side effects of Clexane


And it is a fact that a large proportion of elderly people suffer from some type of heart or circulatory problem.

However, medical advances have allowed the development of drugs that allow treating some of these types of pathology, such as the well-known Sintrom or the drug that we are going to talk about throughout this article: Clexane.


What is the Clexane?

We call Clexane a type of anticoagulant drug widely used in the medical field, in response to complex cardiovascular problems that endanger the lives of those who suffer from them.

As an anticoagulant, its function is to reduce blood clotting, which although it is generally positive since it helps to stop bleeding in specific cases in which this process occurs to a great extent, can make it difficult for the blood to pass. and even provoke a thrombus.

Thus, thanks to the anticoagulant it is possible to keep the blood circulating in a liquid and fluid way and reduce the risk.

Clexane is a drug whose active ingredient is enoxaparin sodium, being one of the low molecular weight heparins (which are derived from non-fractionated ones) that is obtained from the intestines of the pig.

It is a drug whose main route of administration is intravenous or subdermal, and it is marketed as prepared syringes. It is not applied orally or intramuscularly.

Functions of clexane

Clexane is a drug widely used in various conditions in which it can save lives, either as a treatment or even as prevention of some life-threatening situations, all of which are linked to the cardiovascular system.


One of the main indications is in the treatment of deep vein thrombosis, an alteration in which blood clots plug one of the body’s veins, generally directed to the extremities, and which can generate important consequences (including a possible embolism pulmonary).

Also not only during treatment but also as prevention in high-risk cases or to prevent it from happening again in people who have already suffered it before.

It is also used in the treatment of acute coronary syndromes, including some types of angina pectoris and heart attacks, usually as a previous step or in conjunction with other medications, as well as in the prevention of relapses.

Likewise, it is effective in preventing possible thrombi in cases of respiratory or heart failure, as well as in people in a coma or who must remain in a recumbent position (for example, in a long convalescence) and even to prevent possible clots in the case of patients. who must undergo hemodialysis.


It must be taken into account that Clexane can be used at any age from adulthood, including very old ages if necessary.

However, there are not enough studies carried out with minors that allow us to know if it is a safe drug, being a drug that should only be applied to adults.


Possible side effects of clexane

This drug has proven to be very useful and has saved multiple lives since its discovery, but like all drugs, it is not without risks and side effects.

First of all, and as with the rest of anticoagulants, it should be taken into account that the fact that the blood is prevented from clotting causes bleeding of varying severity to arise from any part of the body.

Simple wounds and blows can bleed or generate internal hematomas of great relevance, and it must be necessary to be very careful in this regard. This is the most common secondary symptom.

Likewise, and derived from it, anemia may also appear due to blood loss. Sometimes these hemorrhages can occur at the intestinal, spinal, or intracranial level, being their much greater danger.

The possibility of appearance as well as edema, erythema, alopecia, dermatitis, or even fever has also been observed.

It has been observed that in some cases the level of potassium in the blood increases excessively or even triple the levels of transaminases and other liver enzymes.


More serious are cases of cutaneous necrosis or vasculitis, liver lesions, or thrombocytopenia that can paradoxically generate thrombosis (something that makes it necessary to periodically do a platelet count of the subject).

Contraindications of clexane

As we have seen, despite being very useful, Clexane can also generate dangerous effects, which can put certain sectors of the population at risk. That is why it has various contraindications.

One of these contraindications can be found in the cases of those who have an allergy or hypersensitivity to this drug as well as to other heparins, as well as to its multiple components.

It is contraindicated in people at high risk of bleeding, including people who are going to undergo surgery or are going to have punctures, people with ulcers, aneurysms, or vascular problems in which the walls of the vessels are more fragile.

Also in people with heparin-induced thrombocytopenia. People with high levels of potassium in the blood should avoid it, and it is not recommended in severe kidney failure (with the possible exception of its use in dialysis), as well as extreme caution in the case of liver failure.

It is also not recommended, or at least great caution and control are required, in diabetic patients due to the adrenal alterations it can cause.


Underweight or obese patients should be monitored, as there is a greater risk of bleeding or thrombi.

The use of Clexane in people taking other drugs should be consulted. Finally, and as we have indicated previously since there are no data in this regard, it is contraindicated in children.


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