Health

4 Benefits of sulforaphane and side effects

Published

8 months ago

April 29, 2024

admin

Table of Contents

Health benefits of Sulforaphane
Possible side effects
- Related products
Sulforaphane sources
- How to avoid its degradation in the kitchen
- Discover the 4 shocking health benefits of sulforaphane and side effects.
  Sulforaphane is associated with several health benefits, especially at the cardiovascular and brain level. Do you want to know more about it?
  
  Sulforaphane is a compound found in some vegetables such as broccoli, Brussels sprouts, or kale.
  
  It is a type of isothiocyanate that is primarily responsible for the health benefits of cruciferous consumption.
  
  In particular, it stands out for having anti-inflammatory, antioxidant, and antimicrobial properties.
  
  It is also believed to help prevent cardiovascular disease, some types of cancer, and autism. What does science say about it? Here are all the details.
  
  Sulforaphane and its functions in the body
  
  Sulforaphane is a sulfur compound from the group of isothiocyanates. Cruciferous plants are one of its main sources, in the form of glucoraphanin. This last molecule is deactivated.
  
  For it to break down into sulforaphane, the action of the enzyme myrosinase is necessary, which is activated when the plant is cut, grated, beaten, or chewed. Also, some bacteria in the intestine are capable of doing this.
  
  Glucosinolates such as glucoraphanin exert a protective role in the plants where they are found. They are a protective barrier against pathogens and herbivorous organisms.
  
  Meanwhile, in the human body, one of its main functions is to activate the expression of the NRF2 gene, involved in more than 200 different bodily functions.
  
  In turn, it is responsible for expressing proteins with repairing, antioxidant, detoxifying, or cellular protective activity.
  
  Sulforaphane is mainly found in cruciferous vegetables like broccoli.
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  Health benefits of Sulforaphane
  
  For several years, scientists have focused on the possible positive health effects of sulforaphane.
  
  And although it is necessary to deepen the investigation, some of them can be detailed.
  
  1. Cancer prevention
  
  On numerous occasions, a high intake of cruciferous vegetables has been linked to a lower incidence of cancer.
  
  This activity is largely derived from the presence of isothiocyanates, among which sulforaphane stands out.
  
  As Su, Jiang, Meng, and other authors point out, the mechanisms involved are various.
  
  The result is the inhibition of tumor growth and the activation of apoptosis (death of cancer cells).
  
  Similarly, due to the antioxidant activity, it is possible to stop DNA damage, mutations and inflammation.
  
  These actions are what allow us to think of sulforaphane as a chemopreventive agent in some types of cancer (bladder, cervical, breast, lung, prostate, or colon). It could also improve the effectiveness of a commonly used chemotherapy drug.
  
  However, it is necessary to bear in mind that most studies have been carried out with extracts of sulforaphane.
  
  In addition, the effects have been tested on animals. Therefore, the possible positive effect on humans is unknown.
  
  2. Cardiovascular health
  
  Cardiovascular diseases are a major cause of mortality and morbidity in many countries of the world.
  
  Because of this, ways to reduce its impact and improve the quality of life of those affected have become a public health issue.
  
  About this, sulforaphane has aroused some interest, since its antioxidant activity is beneficial.
  
  Studies in both humans and animals have shown a protective effect against hypertension, arteriosclerosis, or diabetes. Therefore, it is believed that it could protect against heart disease.
  
  3. Autism
  
  The journal of the National Academy of Sciences of the United States published a study to evaluate the use of sulforaphane as a treatment in autism spectrum disorder.
  
  The results show an improvement in the behavior of those affected.
  
  This advance would be related to a protective activity against oxidative stress, inflammation, and DNA damage. However, more research is needed to corroborate this.
  
  4. Neurodegenerative pathologies
  
  This has been another of the research fields that have made it possible to evaluate the ability of sulforaphane to activate different protective responses that could prevent neurodegeneration.
  
  Thus, it would improve memory and prevent diseases such as Alzheimer’s, Parkinson’s, or multiple sclerosis.
  
  Possible side effects
  
  Initially, the intake of cruciferous vegetables that provide sulforaphane is safe and suitable for all people. This is so as long as there are no allergies, intolerance, or digestive problems after eating them.
  
  On the other hand, when it is taken in the form of a dietary supplement, there may be some drawbacks.
  
  The most common are gas, diarrhea, or constipation.
  
  In addition, it must be borne in mind that there are no studies to verify the safety of this compound after prolonged intake or large doses.
  
  For this reason, sometimes it is better to avoid them or consult a doctor before ingesting them.
  
  This is the case of pregnant and lactating women and people who have illnesses or are undergoing medical treatment.
  
  Related products
  
  As discussed, sulforaphane can also be found as a dietary supplement. Its most common presentation is in the form of tablets or powder, almost always made from broccoli or broccoli sprouts.
  
  In this case, these are products with a much higher amount of sulforaphane than that found in vegetables.
  
  Glucoraphanin is its precursor and is also available in capsule or tablet form. It is usually accompanied by myrosinase, an enzyme necessary to activate it and promote the appearance of sulforaphane.
  
  Initially, there are no amounts and dosages established as safe. For this reason, it is advisable to follow the instructions of each manufacturer and always consult a specialist.
  
  Sulforaphane sources
  
  In its natural form, sulforaphane is present in the following vegetables:
  
  Brussels sprouts.
  
  Broccoli.
  
  Broccoli sprouts.
  
  Kale.
  
  Grelos.
  
  Arugula
  
  Cauliflower.
  
  Cabbage.
  
  Lombarda.
  
  The best way to obtain sulforaphane is through foods that provide it naturally. However, these must be eaten raw.
  
  How to avoid its degradation in the kitchen
  
  Some of the positive compounds in foods can be destroyed or modified in the cooking process. This is the case for some vitamins or lipids. And also from sulforaphane.
  
  The highest sulforaphane levels are found in raw foods. However, sometimes it is difficult to eat crucifers without applying some type of cooking.
  
  Luckily, there are some great tips and practices out there to prevent it from completely degrading.
  
  The best way to cook all these vegetables is steamed; specifically between 1 and 3 minutes.
  
  Boiling and all long methods with high temperatures should be avoided.
  
  Also, all foods that contain myrosinase (activator of sulforaphane) are good companions for broccoli, Brussels sprouts, and all crucifers. This compound is present in mustard seeds, for example.
  
  Sulforaphane in cruciferous vegetables may have positive health effects
  
  Sulforaphane is a molecule that is present in some vegetables of the cruciferous family.
  
  In recent years, it has aroused the interest of scientists for its antioxidant properties and its protective effect against some diseases.
  
  The best way to take advantage of all its health benefits is to include cruciferous vegetables in your daily diet.
  
  Likewise, it is essential to accompany them with the intake of other varied vegetables, fruits, and whole grains.
  
  This is because all molecules with positive effects complement each other in their actions.
  
  Thus, a healthy diet and lifestyle are what promote long-term well-being and quality of life.

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Health

Benefits of bay leaves and side effects

Published

8 months ago

April 29, 2024

admin

Table of Contents

Nutrition facts of bay leaf
Health benefits of bay leaves.
How to make bay leaf tea
How to buy and store bay leaf?
Bay leaf history
Side effects of bay leaves
- Blood sugar control
- Pregnancy and most likely breastfeeding
- Surgical problems
- Related
- Discover the 5 shocking health benefits of bay leaves and side effects.
  When you think of bay leaf, you immediately remember the aroma of delicious Italian food cooked on the stove.
  
  This herb has been around for centuries for medicinal purposes, as well as to flavor cooking with a distinctive salty flavor or fragrance for meats, soups, and stews, and even as an ingredient in a cologne known as bay rum, you can find the leaf of bay leaf in cosmetics, soaps, and detergents as well, but beyond that, the benefits of bay leaf are quite recognized worldwide.
  
  Bay leaf is remarkable for its many health benefits, such as helping to treat cancer, gas and bloating, and digestion.
  
  There is even some evidence that it can help treat dandruff, muscle and joint pain, and skin infections, although more research is needed to confirm those uses.
  
  Nutrition facts of bay leaf
  
  One tablespoon (two grams) of the shredded bay leaf contains approximately:
- • 5.5 calories
  • 1.3 grams of carbohydrates
  
  • 0.1 grams of protein
  
  • 0.1 grams of fat
  
  • 0.5 grams of fiber
  
  • 0.1-milligram manganese (7 percent DV)
  
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  • 0.8 milligrams iron (4 percent DV)
  
  • 108 IU vitamin A (2 percent DV)
  
  Find out how to use this ancient herb to get some of these amazing benefits.
  
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  Health benefits of bay leaves.
  
  1.- Antimicrobial and Antioxidant Qualities
  
  Bay leaf benefits, including bay leaf essential oil, offer antimicrobial and antioxidant benefits.
  
  A study conducted at North Carolina State University of Agriculture and Technology focused on the antimicrobial and antioxidant activities of specific essential oils of white wormwood, rose-scented geranium, and bay laurel in fresh produce against Salmonella and E. coli.
  
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  All three essential oils showed antioxidant properties, with the highest activity occurring in bay laurel essential oil.
  
  2.- Benefits of bay leaves for wounds
  
  Bay leaf has been shown to provide antifungal properties. A study was conducted to demonstrate the antifungal potential of the essential oil of bay laurel against candida.
  
  In the study, bay laurel disrupted candida’s adhesion to cell walls, thus reducing its ability to penetrate the membrane, making it a great addition to the candida diet to combat this condition.
  
  In addition to fighting candida, bay leaf has been used as an extract and in a poultice to heal wounds in rats.
  
  While it was not as effective in healing wounds as quickly or as effectively as Allamanda cathartica. L . extract, bay laurel extract showed better wound healing compared to the control group.
  
  3.- Benefits of bay leaves for cancer
  
  The evaluation of the use of laurel extracts showed that both the leaves and the fruits were potent against the cellular models of breast cancer.
  
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  The study notes that bay leaf is a potential natural agent for breast cancer therapy by comparing the cells that were induced with the extracts and those that were not.
  
  Cell death occurred in those that were induced, making bay leaf a possible natural cancer treatment option.https://pubmed.ncbi.nlm.nih.gov/23859043/
  
  Additional research suggests that it may help fight colorectal cancer.
  
  In vitro studies were carried out using extracts of bay leaf against colon cancer cell growth, using a process of incorporation of ingredients, such as bay leaf in food, the results showed the potential for regulatory properties colon cancer, demonstrating its relevance for protection against colorectal cancer during the early stages of detection.
  
  4.- Benefits of bay leaves for diabetes
  
  The benefits of bay leaf may help reduce the levels of sugar in the blood.
  
  Research suggests that when taking ground bay leaves twice a day, blood sugar levels and cholesterol (LDL) levels dropped in study participants.
  
  It is important to note that this study included the regular medication that the subjects were using for diabetes.
  
  However, the benefits were positive, which also shows that it increases good cholesterol (HDL).
  
  Additional research reveals that bay leaf benefits can improve insulin function.
  
  The study was conducted to determine whether bay leaves can help prevent and eliminate type 2 diabetes.
  
  Forty people were given varying amounts of bay leaf, in capsule form, per day for 30 days.
  
  All amounts reduced serum glucose and total cholesterol, but there were no significant changes in the placebo group.
  
  The overall result shows that regular consumption of bay leaves can help lower risk factors for diabetes and even cardiovascular disease.
  
  5.- Benefits of bay leaves for digestion
  
  Bay leaves can have an impact on the gastrointestinal system by promoting urination, which helps to release toxins in the body.
  
  Inside bay leaves are certain organic compounds that contain enzymes that can help eliminate an upset stomach and calm irritable bowel syndrome, reducing bloating and gas.
  
  In some cases, it is known to decrease celiac disease symptoms as well.
  
  In general, bay leaf can provide great relief by enhancing the digestion process and thereby increasing nutrient absorption.
  
  How to make bay leaf tea
  
  Preparing this tea is almost like preparing any other tea. As long as you have the bay leaf and water then you are adequate to go.
  
  It is said that a hot cup of bay leaf tea is superfluous like aromatherapy. The fragrant leaves aid in spicing the tea and give you a taste that leaves you wanting more.
  
  Ingredients
  
  •2 large bay leaves
  •2 cups of water
  •Sugar and milk (not required)
  
  Procedure
  
  •First, carefully add the bay leaf to a pot and pour water into it. Enable boiling for at least three minutes over high heat.
  
  •Remove the pot from the tea and allow the tea to saturate for a little while (like 4 minutes), strain and drink.
  
  •You can deduce to add sugar and milk, but beware that too much can alter the flavor of the tea.
  
  Note: There’s also cinnamon and bay leaf tea which is just another way of enjoying this amazing tea.
  
  To prepare, just add a cinnamon stick to the bay leaf and boil together.
  
  For those looking forward to alleviating that extra kilo, cinnamon in bay leaf tea is a wonderful way to lose weight.
  
  Without the improvement of milk and sugar, the taste of the bay leaf tea usually varies from a pungent, sharp taste to a bitter taste with a nice smell.
  
  If you don’t like the bitter taste, you can add milk and dilute the taste of the tea. The addition of milk and sugar also brings out a more floral taste
  
  How to buy and store bay leaf?
  
  When shopping, look for dried bay leaves that have no blemishes, making sure there are no cracks or tears.
  
  If you’re looking to buy fresh bay leaves, look for ones that are bright green and waxy in color, while allowing for a fold and twist without breaking.
  
  You can cook using the whole bay leaf, but be sure to remove the whole bay leaves from your plate before serving to avoid choking.
  
  While Turkish bay laurel is the most popular, if you opt for California bay leaves, use about half the amount a recipe calls for as it is generally stronger in flavor.
  
  Store the bay leaves by sealing them tightly, such as in a mason jar with a tight-fitting lid. If stored properly, the dried leaves can last up to two years.
  
  Bay leaf history
  
  Bay leaf benefits refer to various plants, including bay laurel, California laurel, Indian laurel, Indonesian laurel or Indonesian laurel, West Indian laurel, and Mexican bay leaf.
  
  However, Turkish bay leaves are the most commonly used type of the ancient tree, Laurus nobilis.
  
  It seems that various references to the laurel species of this aromatic plant may cause some confusion regarding the true bay leaf, but to be a true bay leaf it must have come from the Laurus nobilis tree. It can also be called bay laurel or sweet bay.
  
  The tree is an evergreen tree of the Lauraceae family, native to the Mediterranean. The baby leaf is delicately fragrant with a bitter taste and contains about 2 percent essential oil.
  
  It is more common to use the dry version of the whole leaf when cooking, then remove the leaf from the plate before serving.
  
  The bay leaf dates back to ancient times when laurel wreaths were made to crown victorious athletes in ancient Greece, which inspired the famous crown for winners of the Boston Marathon and the Olympic Games.
  
  In addition, it was Nike, also known as Victoria, and the origin of the name of the well-known Nike sneaker, who led the way of the laurel wreath to adorn the heads of athletes around the world.
  
  Representing the goddess of strength, speed, victory, glory, and fame, Nike flew across the battlefields rewarding the winners with the now-famous wreath of laurel leaves (laurel leaves).
  
  Due to its menthol-like fragrance, it was called Baywood pepperwood by early European settlers.
  
  The Salinan Indians created a poultice to help those suffering from seizures by combining bay leaves with cinnamon, nutmeg, and olive oil, and some tribes placed a single leaf in the nostril to cure headaches.
  
  It was even used to attract deer by some hunters. And let’s not forget the fun of the Karok Indian children throwing the leaves into the fire to make a firecracker sound.
  
  Side effects of bay leaves
  
  Here are some of the side effects of consuming bay leaf tea.
  
  Blood sugar control
  
  Although consuming bay leaf tea assists in lowering blood sugar levels, there have been grievances of the leaf doing otherwise.
  
  Consult your doctor if you are already on medications for high blood sugar issues.
  
  Pregnancy and most likely breastfeeding
  
  There isn’t much thorough study on how bay leaf tea influences pregnancy, but as they say, prevention is better than the cure.
  
  Please be on the safe side and avoid consuming the bay leaf tea when you are pregnant.
  
  Surgical problems
  
  The bay leaf manages to slow down the central nervous system, meaning that problems can arise during surgery when anesthesia is administered.
  
  It is therefore advisable to avoid consuming the bay leaf tea for a couple of weeks before undergoing surgery.
  
  Final thoughts
  
  Bay leaf is a classic spice that can be that special ingredient in almost any dish. The addition of spices not only adds delicious flavor but can also offer many health benefits;
  
  For example, bay leaves or the essential oil derived from them have been shown to help prevent candida, heal wounds, fight cancer, and aid digestion.
  
  In addition, they are useful in diabetics because of the evidence that they can help control blood sugar and lower cholesterol.
  
  This herb also has antimicrobial and antioxidant properties, and while more research is needed to confirm efficacy, evidence shows that it can help treat dandruff, muscle and joint pain, and skin infections.
  
  As you can see, this herb can do quite a bit. If you haven’t cooked with bay leaf, start with small amounts.
  
  You can divide the bay leaves in half or use the fresh or ground versions, and start getting the great taste and benefits this herb has to offer.

Health

Serious side effects of metoprolol

Published

8 months ago

April 29, 2024

admin

Discover the serious side effects of metoprolol.
How does this medication work? What are its effects?
Metoprolol belongs to the class of medications called beta-blockers. Metoprolol is used to treat high blood pressure and prevent symptoms of certain types of angina ( chest pain). It is also used to reduce the risk of death immediately after a heart attack. It works by reducing the needs of the heart during exercise.
People who have had a heart attack take metoprolol to avoid having another heart attack. Metoprolol is often used in combination with other drugs that lower high blood pressure, such as diuretics (pills that increase urine output), when just one agent is not enough to control blood pressure.
This medicine is available under various brand names or in different formulations, or both. A specific brand of this medication may not be available in all forms and may not have been approved for all of the conditions discussed here. Also, some forms of this medicine may not be used for all of the conditions mentioned in this article.
Your doctor may have suggested this medication for a condition that is not listed in this Medication Information article. If you have not yet discussed this with your doctor, or if you are not sure why you are taking this medicine, consult your doctor. Do not stop taking this medicine without consulting your doctor first.
Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.
What forms does this medication come in?
Apo-Metoprolol
25 mg
Each white, oval, scored tablet, engraved “ME” over “25” on one side and “APO” on the other, contains 25 mg of metoprolol tartrate. Nonmedicinal ingredients: colloidal silica dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.
50 mg
Each white, round, scored tablet, engraved “APO” over “M50”, contains 50 mg of metoprolol tartrate. Nonmedicinal ingredients: colloidal silica dioxide, croscarmellose sodium, lactose, magnesium stearate, and microcrystalline cellulose.
100 mg
Each white, round, scored tablet, debossed with “APO” over “M100”, contains 100 mg of metoprolol tartrate. Nonmedicinal ingredients: colloidal silica dioxide, croscarmellose sodium, lactose, magnesium stearate, and microcrystalline cellulose.
Apo-Metoprolol (Type L)
50 mg
Each pink, capsule-shaped, coated tablet, scored on one side and engraved “50” on the other, contains 50 mg of metoprolol. Nonmedicinal ingredients: carnauba wax, colloidal silica dioxide, croscarmellose sodium, D&C aluminum lake red No. 30, sun yellow aluminum lake, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol 3350, and sodium dioxide. titanium.
100 mg
Each blue, capsule-shaped, coated tablet, scored on one side and engraved “100” on the other, contains 100 mg of metoprolol. Nonmedicinal ingredients: carnauba wax, colloidal silica dioxide, croscarmellose sodium, hydroxypropylmethylcellulose, indigotin aluminum lake (AD & C blue # 2), lactose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol 3350, and titanium dioxide.
How should this medication be used?
The usual maintenance dose of metoprolol ranges from 100 mg to 200 mg per day, however, this dose may be increased to 400 mg per day as needed to achieve symptom control. Immediate-release tablets are taken in 2 divided doses while slow-release tablets are taken once a day.
This medication should be taken soon after a meal, but try to take it at the same time every day.
Several factors can be taken into account in determining the dose a person needs: their weight, their health, and whether they are taking other medications. If your doctor has recommended a dose other than those listed here, do not change the way you are taking the medicine without consulting your doctor.
This medicine must be taken exactly as your doctor has told you. If you miss a dose, take the medicine as soon as you notice the missed dose and resume treatment as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your usual dosing schedule. Do not use a double dose to make up for a missed dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medicines in the wastewater (eg not in the sink or in the toilet bowl) or with the household garbage. Ask your pharmacist how to dispose of unused or expired medicines.
In which cases is this medication not recommended?
Do not use this medicine under the following circumstances:
a condition such as right ventricular failure caused by high blood pressure in the lungs;
is allergic to metoprolol or any of the ingredients of the medication
are allergic to other beta-blockers;
anesthesia caused by an agent having a depressant effect on the myocardium (eg ether);
a history of heart attack accompanied by:
a heart rate of fewer than 45 beats per minute,
severe heart block
very low blood pressure
moderate or severe heart failure.
slow heartbeat caused by problems with the heart rhythm;
severe heart block;
cardiogenic shock;
significant circulatory disorders;
proven heart failure;
the presence of asthma or other obstructive airway conditions (only when it comes to metoprolol in intravenous form);
a disorder referred to as “sinus dysfunction syndrome”;
have untreated pheochromocytoma (a tumor of the adrenal glands).
What are the possible side effects of metoprolol
Many medications can cause side effects. A side effect is an unwanted response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
At least 1% of people taking this medicine reported the following side effects. Many of these side effects can be managed and a few may go away on their own over time.
Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects appear:
changes in libido or sexual ability;
constipation;
diarrhea;
pain or discomfort in the abdomen;
dizziness or light-headedness when changing from sitting or lying down to standin
fatigue or unusual weakness brought on by activity;
fatigue;
headaches;
nausea;
hair loss;
weight gain;
dreams giving a powerful sensation;
dry mouth;
increased sensitivity of the skin to solar radiation;
increased sweating;
sleep disturbances;
vomitings.
Most of the side effects listed below do not happen very often, but they could cause serious problems if you do not see your doctor or receive medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
slow heartbeat (especially less than 40 beats per minute);
hearing changes;
confusion;
difficulty breathing or wheezing;
back or joint pain;
chest pain;
hallucinations (the perception of phenomena that do not exist);
tingling in the arms and legs.
a feeling of coldness in the hands and feet;
signs of depression (eg, lack of concentration, weight fluctuations, trouble sleeping, indifference to many activities, thoughts of suicide);
signs of certain heart problems (e.g., increased or irregular heartbeat or pulse, chest pain, difficulty breathing, excessive fatigue, swelling of the feet, ankles, or part lower legs);
signs of certain kidney problems (eg increased or reduced urine production, itching, nausea, vomiting, rash);
signs of a bleeding disorder (e.g. unusual nosebleeds, bruising, blood in urine, cough with bloody sputum, bleeding gums, cuts that keep bleeding) ;
signs of liver problems (eg, nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools );
a flare-up of psoriasis (eg, red spots the size of a pinhead on the skin; red, scaly, or crusty skin);
a feeling of numbness or tingling in the extremities;
symptoms of low blood pressure (eg, dizziness, fatigue);
vision changes (eg blurred vision, dry eye, eye pain).
Stop taking the drug and seek immediate medical attention if there is a response such as :
coldness, discoloration, or pain in the fingers or toes;
symptoms of a serious allergic reaction (such as swelling of the face or swelling of the throat, hives, or difficulty breathing).
Some people may experience side effects other than those listed. See your doctor if you notice any symptom that worries you while you are using this medicine.
Are there other precautions or warnings?
Before using any medication, be sure to tell your doctor about any medical conditions or allergies you may have, the medications you are using, and any other important facts about your health. Women should mention if they are pregnant or breastfeeding. These factors could influence how you should use this medicine.
Respiratory disorders: In general, people with asthma, and certain other lung problems, should generally avoid taking beta-blockers such as metoprolol, as they can cause breathing difficulties. If you have breathing problems, and your doctor has prescribed metoprolol for you, it is probably in lower doses, and they will monitor you regularly while you are using this medicine. If you have breathing problems, talk to your doctor about how this medicine may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed. specific.
Severe allergies: If you have allergies severe enough to cause anaphylaxis (a severe allergic reaction in which swelling of the face, lips, and throat makes it very difficult to breathe), talk to your doctor about what to do next. take if you have an allergic reaction. the use of metoprolol may make it more difficult to treat severe allergic reactions with epinephrine.
Stopping the drug: People with heart disease who suddenly stop taking this drug may experience chest pain, irregular heartbeat, or a heart attack. If you have heart disease, do not stop taking this medication without consulting your doctor first. When this medication is to be stopped, it should be done gradually, under the supervision of your doctor.
Diabetes: The signs associated with low blood sugar may be more difficult to see while you are taking metoprolol. People with diabetes may have a harder time regulating their blood sugar levels when taking this medicine. If you have diabetes, discuss with your doctor how this medication may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed. specific. You will be kept under medical supervision while taking this medicine and your doctor may need to adjust your doses of diabetes medicine.
Dizziness or syncope: Metoprolol may cause side effects, including dizziness or fainting, soon after starting treatment. Do not drive a vehicle or do other potentially dangerous tasks until you know how this medicine works for you.
Hyperthyroidism (high level of thyroid hormones): Metoprolol may mask the symptoms of a person with hyperthyroidism (high level of thyroid hormones).
If you have hyperthyroidism, discuss with your doctor how this medication may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether it is appropriate to have it. specific medical surveillance. Stopping the medication suddenly could make this condition worse.
Liver function: Liver disease or reduced liver function can cause this drug to build up in the body, causing side effects. If you have liver problems, talk to your doctor about how this medicine may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed. specific. Your doctor will monitor your liver function with regular blood tests while you are taking this medicine.
If you notice symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain, or swelling and itching of the skin, contact your doctor immediately.
Kidney function: Taking metoprolol may affect kidney function. Your doctor will take this into account in his monitoring and will adjust your dose as needed. If you have reduced kidney function or kidney disease, talk to your doctor about how this medicine may affect your condition, how your condition affects the administration, and how well this medicine works. , and the relevance of specific medical surveillance. If you notice swelling in your hands, feet, or face, an increase in your blood pressure, unusual muscle cramps, or a dark appearance of your urine, this medicine may be interfering with the proper function of your blood. kidneys.
If you notice any of these symptoms, contact your doctor as soon as possible.
Heart disease: Beta-blockers like metoprolol can worsen already present heart failure. It is essential to use metoprolol as prescribed by your doctor to reduce this risk. If you have a history of heart disease, discuss with your doctor how this medication may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether it is appropriate to use it. specific medical surveillance.
Pheochromocytoma: This medicine may worsen the symptoms of pheochromocytoma (a tumor of the adrenal gland) if taken alone Talk to your doctor about how this medicine might affect your condition, how your condition affects your condition. administration and efficacy of this medicinal product, and the relevance of specific medical supervision.
Surgery: If you are about to have surgery, tell all healthcare professionals who treat you that you are using metoprolol.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If pregnancy occurs while you are using this medicine, contact your doctor immediately.
Breast-feeding: This medicine passes into breast milk. If you use metoprolol while you are breastfeeding your baby may feel the effects. Check with your doctor to see if you should continue breastfeeding.
Children: The safety and effectiveness of this medicine have not been established in children
Seniors: Normal doses of metoprolol for adults may lower blood pressure more than expected. Lower doses may be necessary for the elderly.
Can other agents interact with this medication?
There may be an interaction between metoprolol and any of the following:
abiraterone acetate;
acetylcholine;
anesthetic agents;
alpha agonists (eg, clonidine, methyldopa);
alcohol;
aldesleukin;
aliskiren;
alpha1-blockers (eg doxazosin, prazosin, tamsulosin);
amifostine;
amiodarone;
amphetamines (eg, dextroamphetamine, lisdexamfetamine);
serotonin antagonists (antiemetic drugs; eg dolasetron, granisetron, ondansetron);
tricyclic antidepressants (eg amitriptyline, clomipramine, desipramine, trimipramine);
antihistamines (eg, cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine, diphenhydramine);
nonsteroidal anti-inflammatory drugs (NSAIDs) eg. ibuprofen, indomethacin, naproxen);
antimalarials (e.g. chloroquine, hydroxychloroquine, mefloquine, quinine);
antipsychotics (eg, chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone);
asunaprevir;
atomoxetine;
other beta-blockers (eg, atenolol, pindolol, propranolol);
azelastine;
barbiturates (eg, butalbital, pentobarbital, phenobarbital);
beta-agonists (anti-asthma medicines, eg salbutamol, salmeterol, formoterol);
calcium channel blockers (eg, verapamil, diltiazem, nifedipine, amlodipine);
angiotensin II receptor blockers (ARBs) eg. irbesartan, losartan);
bortezomib;
brimonidine;
buprenorphine;
bupropion;
celecoxib;
ceritinib;
milk thistle;
cholecalciferol;
cimetidine;
cinacalcet;
clobazam;
clotrimazole;
cobicistat;
cocaine;
cyproterone;
darifenacin;
delavirdine;
rye ergot derivatives (eg bromocriptine, ergotamine, methylergonovine);
nitro derivatives (eg nitroglycerin, isosorbide dinitrate, isosorbide mononitrate);
dextromethorphan;
digoxin;
dipyridamole;
disopyramide;
disulfiram;
diuretics (pills to remove water; eg furosemide, hydrochlorothiazide);
donepezil;
doxorubicin;
dronedarone;
entacapone;
epinephrine;
grass pollen allergen extract;
fentanyl;
fingolimod;
flecainide;
floctafenine;
galantamine;
ginger;
ginseng;
guanfacine;
imatinib;
phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil);
proton pump inhibitors (eg, lansoprazole, omeprazole, rabeprazole);
Angiotensin-Converting Enzyme Inhibitors (ACEIs) eg. captopril, ramipril);
selective serotonin reuptake inhibitors (eg fluoxetine, paroxetine, sertraline);
selective serotonin-norepinephrine reuptake inhibitors or SNRIs (eg, desvenlafaxine, duloxetine, venlafaxine);
insulin;
isoniazid;
ketoconazole;
lacosamide;
lanreotide;
levodopa;
lidocaine;
lomustine;
cholesterol “statin” drugs (eg pravastatin, simvastatin);
methacholine;
methadone;
methimazole;
methoxsalen;
methylphenidate;
metoclopramide;
midodrine;
mifepristone;
mirabegron;
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moclobemide;
nefazodone;
nevirapine;
nilotinib;
noradrenaline;
octreotide;
orphenadrine;
oxybutynin;
pasireotide;
pazopanib;
peginterferon alfa-2b;
pentoxifylline;
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sodium phenylbutyrate;
pilocarpine;
pimozide;
praziquantel;
propafenone;
quinidine;
quinine;
ranitidine;
regorafenib;
rifabutin;
rifampin;
rituximab;
rivastigmine;
ropinirole;
sulfonylureas (eg gliclazide, glyburide, tolbutamide);
temsirolimus;
terbinafine;
theophyllines (eg aminophylline, oxtriphylline, theophylline);
ticagrelor;
ticlopidine;
tizanidine;
tofacitinib;
tolcapone;
tranylcypromine;
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yohimbine.
If you are taking any of the above medicines, please tell your doctor or pharmacist. In your case, your doctor may ask you to:
stop taking any of the medications;
replace one of the drugs with another;
change the way you take one or both of the medicines.
do not change anything at all.
Interference of one medicine with another does not always mean that you stop taking one of them. Ask your doctor what to do with drug interactions.
Drugs other than those listed above may interact with this drug. Tell your doctor everything you take, whether it is prescription or over-the-counter drugs and herbal remedies. Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine, or street drugs, you should tell your prescribing doctor since these substances can affect the way many drugs work

Health

Side effects of too much cinnamon

Published

8 months ago

April 29, 2024

admin

Table of Contents

The different types of cinnamon
The particular case of Chinese cinnamon (cassia) and its side effects
Contraindications for cinnamon
Side effects of too much cinnamon
Interactions between cinnamon and drugs
Cinnamon during pregnancy and lactation
Side effects of too much cinnamon, the dangers and contraindications associated with cinnamonCinnamon is an excellent spice for your health and has exceptional health benefits. However, in some cases, and like all herbal medicine plants, cinnamon can cause certain unwanted harmful effects, which is why it is important to know what these harmful effects are and when can they occur before consuming them.

The different types of cinnamon

Indeed, two types of cinnamon come from the bark of two very similar, but different, tree species:

•Cinnamomum Verum, known as Ceylon cinnamon, also known as real cinnamon.
•Cinnamomum aromaticum or Cinnamomum cassia, called cinnamon from Indonesia or China, also called false cinnamon.

Let’s be clear, to take advantage of the virtues of cinnamon, the variety does not matter, they have almost the same effect. That said, for high dose or long term use, cassia cinnamon will be more harmful to health.

Indeed, their actions for health are the same, with one exception that makes all the difference: coumarin. It is the coumarin concentration that differs in the two species. Ceylon cinnamon bark (Cinnamomum Verum) hardly contains any, but on the other hand, Chinese cinnamon bark (Cinnamomum cassia) is rich in it.

Except for that coumarin, at a certain dose, is potentially toxic to the liver and kidneys.

The particular case of Chinese cinnamon (cassia) and its side effects

As we just saw, Chinese cinnamon, or cassia cinnamon, is high in coumarin, a potentially toxic compound. Indeed, this natural substance, in high concentration, causes damage to the liver and kidneys.

The maximum daily amount of coumarin in the diet is estimated to be 0.1 mg coumarin per pound of body weight. For example, for a person weighing 60 kg, it should not exceed 6 mg of coumarin per day, which corresponds to about 4 or 5 g of Chinese cinnamon per day.

So my advice is, if you have liver problems, no doubt, take Ceylon Cinnamon (Cinnamomum Verum). If you have a large consumption of cinnamon, that is to say, daily consumption and inconsistent dosages (say 5 g per day), then you should also take Ceylon cinnamon.

If you have neither liver problems nor a heavy consumption of cinnamon, it’s up to you, but Indonesian cinnamon (Cinnamomum Cassia) is cheaper, so… For the rest of the article we will cover of the possible dangers of Ceylon cinnamon.

Contraindications for cinnamon

Ceylon cinnamon is a so-called “safe” spice, however, as a precaution, cinnamon is contraindicated in:

•people with heart disease
•people with stomach ulcers
•people allergic to this plant
•pregnant women and babies (before 6 months)
These people should take advice from their doctor or gynaecologist before taking cinnamon, whether for food or therapeutic use. It is contraindicated in babies under 6 months, but it is possible to start incorporating cinnamon in babies over 6 months.

Note that cinnamon, in the form of essential oil, is dermocaustic, that is to say, it can irritate, even burns of the skin and mucous membranes such as the mouth, eyes, oesophagus, etc. It is therefore important not to use it purely on the skin, but to dilute it to at least 3%, and avoid taking it orally, even diluted.

Side effects of too much cinnamon

The side effects of cinnamon are rare or nonexistent. According to medical research, the effect of the spice in the diet is safe.

However, in high doses, it can cause some side effects, but without serious consequences, the most common are:

•Nausea
•Headache
•Heart palpitations

•One-time hypertensive effect

Interactions between cinnamon and drugs

Antidiabetics
Cinnamon is well known for its anti-diabetic properties, it is even called poor man’s insulin, so by combining the spice with taking anti-diabetic drugs, their effects are increased, and this can lead to side effects such as hypoglycemia, excessive sweating, tremors, visual disturbances, dizziness, anxiety, etc.

You should therefore be particularly careful in this case because the effects of cinnamon on blood sugar are very powerful.

Among the most common antidiabetics are biguanides, sulfonylureas, meglitinides, thiazolidinediones, DPP-4 inhibitors, SGLT2 inhibitors, alpha-glucosidase inhibitors, bile acid sequestrants. , etc.

Be careful, it is not only drugs that can have an action on the blood sugar level, some plants or spices can also have the same properties, among the most common: fenugreek, moringa, chlorella, etc.

Anticoagulants
Cinnamon has anticoagulant properties, so its consumption, food and therapy, associated with anticoagulant or antiplatelet treatment, must be done with the informed advice of a doctor.

Indeed, the anticoagulant effects of cinnamon will increase the thinning effects of drugs, which can have serious consequences (bleeding, haemorrhaging, bruising, etc.).

Among the most common anticoagulant and antiplatelet drugs are aspirin (acetylsalicylic acid), clopidogrel (Plavix), dipyridamole (Persantine), AVK (anti-vitamin K), ticlopidine (Ticlid), warfarin (Coumadin) ), enoxaparin (Lovenox), heparin, etc.

Be careful, it is not only drugs that can be anticoagulants, some plants or spices can also have the same properties, among the most common: garlic, ginger, ginkgo, ginseng, tonka beans, etc.

Other interactions
In general, it is not recommended to take cinnamon in parallel with a drug treatment prescribed for cardiovascular diseases without the approval of a doctor.

If you are following a drug slimming treatment, be careful, because cinnamon has slimming properties that can be added to those of drugs.

Likewise, its consumption is not recommended in people undergoing treatment for ulcers.

Cinnamon during pregnancy and lactation

As a precautionary principle, the European Medicines Agency recommends not to take cinnamon during pregnancy or breastfeeding, except for food use. So there is no problem in putting a little cinnamon in the food but a small amount.

Indeed cinnamon is used to treat the absence of menstruation and to help the elimination of stagnant blood, moreover, in India, it is advisable to consume cinnamon milk to accelerate childbirth by stimulating the contractions of the uterus, therefore to be avoided during pregnancy.