Categories: Side effects

Serious side effects of prednisone

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Discover the serious side effects of prednisone.

How does prednisone work? What are its effects?

Prednisone belongs to the group of medicines called corticosteroids. It is used to treat various disorders.

Most often, it is prescribed to treat allergic reactions, certain skin conditions, severe asthma attacks, and arthritis.

It can also be used to treat corticosteroid deficiency, certain blood disorders, certain forms of cancer and, finally, ulcerative colitis.

It works by reducing swelling, inflammation and irritation, suppressing the body’s immune response, or replacing steroids when the body is not making enough.Shocking side effects of prednisone

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Your doctor may have suggested this medicine for a condition that is not listed in this Medication Information article.

Also, some forms of this medicine may not be used for all of the conditions mentioned in this article.

If you have not yet discussed this with your doctor, or if you are not sure why you are taking this medicine, consult your doctor.

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Do not stop taking this medicine without consulting your doctor first.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.

What forms does this medication come in?

5 mg

Each white, round, biconvex, flat, bevelled-rimmed, scored tablet, debossed “N” over “5” on one side, contains prednisone 5 mg.

Nonmedicinal ingredients: colloidal silica dioxide, lactose, magnesium stearate, pregelatinized starch, sodium lauryl sulfate, and sodium starch glycolate.

50 mg

Each white, round, scored tablet, debossed with “novo” over “50” on one side, contains 50 mg of prednisone.

Nonmedicinal ingredients: pregelatinized starch, lactose, sodium lauryl sulfate, colloidal silica dioxide, and magnesium stearate.

How should this medication be used?

The dose of prednisone can vary a lot depending on the condition being treated and your characteristics.

Prednisone should be taken with food to prevent an upset stomach. If the treatment has been for a long time, it should not be interrupted without discussing it with the doctor first.

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The dose should be reduced gradually according to the doctor’s instructions when treatment is stopped.

There are several factors that can be taken into account in determining the dose a person needs: their weight, their health, and whether they are taking other medications.

If your doctor has recommended a dose other than those listed here, do not change the way you are taking the medicine without consulting your doctor .

It is very important to take this medicine exactly as prescribed by your doctor. You should not stop taking this medicine without discussing it with your doctor first.

If you miss a dose, take the medicine as soon as you notice the missed dose and resume treatment as soon as possible.

If it is almost time for your next dose, skip the missed dose and go back to your usual dosing schedule.

Do not use a double dose to make up for a missed dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

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This medicine is available under various brand names or in different formulations, or both.

One brand of this medicine may not be available in all of the formats listed here.

You will find the various formats in which this particular brand is made available to you in the section: “What forms does this medicine take?” “.

Do not dispose of medicines in the waste water (eg not in the sink or in the toilet bowl) or with the household garbage. Ask your pharmacist how to dispose of unused or expired medicines.

In which cases is this medication not recommended?

Do not use this medicine under the following circumstances:

is allergic to prednisone or to any of the ingredients of the medication

the planned administration of a live virus vaccine (e.g. against measles, mumps, rubella or yellow fever or BCG vaccine) to a person who is taking a large dose of prednisone because it has an immunosuppressive effect .

an internal fungal infection;

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the presence of an eye infection caused by the herpes simplex virus, except when urgent short-term treatment of an allergic-type reaction is required;

the presence of measles or chickenpox, except when urgent short-term treatment of an allergic-type reaction is required;

the presence of peptic ulcers (stomach ulcers);

the presence of diverticulitis;

the presence of inflammation of the digestive system of an unknown nature (nonspecific colitis);

the presence of a viral or bacterial infection not controlled by anti-infective drugs.)

What are the possible side effects of prednisone

Many medications can cause side effects. A side effect is an unwanted response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medicine.

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If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medicine reported the following side effects.

Many of these side effects can be managed and a few may go away on their own over time.

Consult your doctor if you experience these side effects and if they are serious or bothersome.

Your pharmacist may be able to give you advice on what to do if these side effects appear:

acne;

altered taste sensations;

the appearance of purplish red lines on the arms, face, legs, trunk or groin;

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increased appetite;

heartburn;

uncommon excessive hair growth;

diarrhea;

abdominal pain;

dizziness;

unusual tiredness or weakness;

decreased fertility (men);

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hiccups;

nausea;

headaches;

irregular periods;

thin, shiny skin;

weight gain;

thinning of the hair;

a feeling of bloating;

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feeling generally unwell;

increased sweating;

sleep disturbances;

vomitings.

Most of the side effects listed below do not happen very often, but they could cause serious problems if you do not see your doctor or receive medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

changes in mood or behavior (eg, aggression, feelings of rage, anxiety or excitement);

confusion;

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muscle cramps or spasms;

pain in the arms, back, hips, legs, ribs, or shoulders;

eye pain;

unusual bruising;

a rash;

muscle weakness;

a false sense of well-being;

hallucinations;

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excessive slowness in healing wounds;

high blood pressure;

an irregular heartbeat;

filling or rounding of the face;

stunted growth (for children);

fluid retention (eg rapid weight gain, swelling of the feet or lower legs);

signs of heart problems (eg, irregular or fast heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, swelling of the legs);

signs of infection (symptoms which may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss or depression);

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symptoms of reactivation of tuberculosis (eg, blood in sputum, chest pain);

symptoms of depression (eg, lack of concentration, weight fluctuations, trouble sleeping, indifference to many activities, thoughts of suicide);

symptoms of a stomach ulcer (eg, persistent stomach or abdominal pain or a burning sensation in the stomach, bloodstained, blackish or sticky stools);

symptoms of high blood sugar (eg, frequent urination, increased thirst, excessive appetite, unexplained weight loss, poorly healing sores, infections, fruity breath);

a tendency to forget;

blurred vision or reduced visual acuity.

Stop taking the drug and seek immediate medical attention if there is a response such as:

convulsions;

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signs of a scleroderma renal crisis (eg, increased blood pressure, reduced urine output);

symptoms of a severe allergic reaction, eg. :

difficulty breathing;

swelling of the face, mouth, tongue or throat;

hives.

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Some people may experience side effects other than those listed. See your doctor if you notice any symptom that worries you while you are using this medicine.

Are there other precautions or warnings?

Before using any medication, be sure to tell your doctor about any medical conditions or allergies you may have, the medications you are using, and any other important facts about your health.

Women should mention if they are pregnant or breastfeeding. These factors could influence how you should use this medicine.

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Stopping the medication: Do not stop taking this medication without consulting your doctor first.

To stop prolonged treatment with prednisone, the dose should be reduced gradually, as directed by your doctor.

Suddenly stopping the drug after long-term treatment with prednisone may lead to corticosteroid withdrawal symptoms, including nausea, fatigue, loss of appetite, fever, muscle or joint pain, and severe pain. generalized malaise.

Electrolytes and fluids: If you take a large dose of prednisone, you may need to limit your salt intake and take potassium supplements. Ask your doctor if you need any supplements while taking this medicine.

In addition, your body may hold more fluid, which can cause your blood pressure to rise. Your doctor will check if this is the case by measuring your blood pressure and ordering blood tests to check your electrolyte levels.

Liver function: Liver disease or reduced liver function can cause this drug to build up in the body, causing side effects.

If you have liver problems, talk to your doctor about how this medicine may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed. specific.

Thyroid function: When the thyroid gland is not functioning normally, the effects of corticosteroids on the body are increased and the risk of side effects increases.

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If you have an underactive thyroid ( hypothyroidism ), discuss with your doctor how this medicine may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether it is appropriate for you. ” specific medical surveillance.

Infections: This medicine may hide some signs of infection, and new infections may occur during treatment with prednisone.

If you notice symptoms of an infection (eg fever, chills, cough, sore throat) or if you come into contact with people who have measles or chickenpox, contact your doctor at most. early.

Osteoporosis: This medication may increase the risk of osteoporosis (weak bones). Ask your doctor for advice about ways to help prevent osteoporosis. If you take this medicine for a long time, your doctor will monitor your bone density.

Blood pressure: Like other corticosteroids, prednisone can cause fluid retention which leads to high blood pressure; this is because the heart has to work harder to circulate the excess fluid in the blood vessels.

If your blood pressure is high or if you are at risk for hypertension, discuss with your doctor how this medicine may affect your condition, how your condition affects administration and how well it works. of this medicine, and the relevance of specific medical supervision.

Stomach and bowel problems: If you have a current or past stomach or bowel ulcer, or ulcerative colitis, talk to your doctor about how this medicine may affect your condition, influence of your condition on the administration and effectiveness of this medicine, and the relevance of specific medical supervision.

Eye problems: Long-term treatment with prednisone can lead to glaucoma and possible damage to the optic nerve, or even cataracts. It can also increase the risk of an eye infection caused by a fungus or virus.

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Report any changes in vision and any eye pain, irritation, redness, or discharge to your doctor as soon as possible.

Kidney problems: Prednisone can be used to treat certain specific kidney problems. This medicine can also cause fluid retention and electrolyte changes that affect kidney function.

If you have kidney damage or reduced kidney function, talk to your doctor about how this medicine may affect your condition, how your condition affects how well this medicine is given and how well it works, and what to do with it. the relevance of specific medical surveillance.

Mental health: Prednisone, like other corticosteroids, can cause behavior and personality changes as well as mood swings. These reactions are more likely to happen when you start taking the medicine.

If you notice these symptoms in yourself or a family member taking this medication, contact your doctor as soon as possible.

Unusual stress: If you are under unusual physical stress (eg trauma, surgery) your doctor may increase your dose of prednisone during and after this stressful episode.

High blood sugar: Prednisone can raise blood sugar levels. Your doctor may order blood tests to monitor your blood sugar levels while you are taking this medicine.

If you have diabetes, discuss with your doctor how this medicine may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed. specific.

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If you are excessively thirsty or pass more urine while taking this medication, contact your doctor.

Medical treatment: Tell all doctors you see that you are taking this medicine.

Vaccination: Taking this medicine at the time of vaccination may reduce the effectiveness of the vaccine and increase the likelihood of some side effects.

Therefore, it is generally recommended that you do not receive a vaccine while you are taking prednisone, especially if you are taking a high dose.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If pregnancy occurs while you are using this medicine, contact your doctor immediately.

Breast-feeding: This medicine passes into breast milk. If you use prednisone while breastfeeding your baby may feel the effects.

Check with your doctor to see if you should continue breast-feeding. If you are taking a high dose of prednisone, your doctor may advise you not to breast-feed.

Children: Since prednisone can slow the growth and development of infants and children, it should not be taken for an extended period of time if possible. Your child’s doctor will monitor your child’s growth and development closely.

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Can other agents interact with this medication?

There may be an interaction between prednisone and any of the following:

acetylsalicylic acid (ASA);

aldesleukin;

amphotericin B;

androgens (eg testosterone);

nonsteroidal anti-inflammatory drugs or NSAIDs (eg, diclofenac, ibuprofen, ketorolac, naproxen);

antacids (eg, aluminum hydroxide, calcium carbonate, magnesium hydroxide);

antibiotics of the quinolone family (eg ciprofloxacin, norfloxacin, ofloxacin);

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anticholinesterases (eg neostigmine, pyridostigmine);

diabetes medicines (eg chlorpropamide, glyburide, insulin, metformin, rosiglitazone, saxagliptin);

antifungals whose name ends in “azole” (eg, itraconazole, ketoconazole, voriconazole);

aprepitant;

aripiprazole;

BCG;

calcitriol;

carbamazepine;

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celecoxib;

cholestyramine;

clarithromycin;

cobicistat;

colestipol;

conivaptan;

cyclosporine;

deferasirox;

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delavirdine;

denosumab;

diltiazem;

diuretics (pills to remove water; eg furosemide, hydrochlorothiazide);

donepezil;

echinacea;

enzalutamide;

fingolimod;

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galantamine;

hyaluronidase;

indacaterol;

HIV protease inhibitors (eg, atazanavir, darunavir, lopinavir, ritonavir);

isoniazid;

leflunomide;

mifepristone;

mitotane;

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natalizumab;

nivolumab;

estrogens (eg, conjugated estrogens, estradiol, ethinyl estradiol, especially oral contraceptives containing estrogen);

phenobarbital;

phenytoin;

pimecrolimus;

primidone;

rifabutin;

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rifampin;

roflumilast;

salicylates (eg ASA);

somatropin;

tacrolimus;

tofacitinib;

trastuzumab;

vaccines or toxoids (eg BCG, measles, mumps, rubella, chickenpox);

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warfarin.

If you are using any of these medicines, talk to your doctor or pharmacist. In your case, your doctor may ask you to:

stop taking any of the medicines,

replace one of the drugs with another,

change the way you take one or both of the medicines

do not change anything at all.

Interference of one medicine with another does not always mean that you stop taking one of them. Ask your doctor what to do with drug interactions.

Drugs other than those listed above may interact with this drug. Tell your doctor about anything you use, whether it is prescription or over-the-counter medications, and herbal remedies.

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Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine (when smoking cigarettes), or street drugs, you should tell your prescribing doctor since these substances can affect the way many drugs work.

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