Categories: Side effects

Serious side effects of Effexor

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lbobvalla
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Discover the serious side effects of Effexor.

How does this medication work? What are its effects?

Venlafaxine belongs to the class of antidepressant and anti-anxiety medications called selective serotonin and norepinephrine reuptake inhibitors or SSRIs. It is used to treat depression. It works on the central nervous system (CNS) to lift the mood of people with depression.Shocking side effects of effexor

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Venlafaxine is also used to treat symptoms of anxiety that cause distress in generalized anxiety disorder (GAD), social anxiety (also called social phobia), and panic disorder (panic attacks). ).

SNRIs work by increasing the amount of 2 neurotransmitters (chemical messengers) called serotonin and norepinephrine, located in parts of the brain.

Symptoms may improve within 2 weeks of starting treatment, but it may take several weeks for the full benefits of this medicine to be fully realized.

This medicine is available under various brand names or in different formulations, or both.

A specific brand of this medication may not be available in all forms and may not have been approved for all of the conditions discussed here.

Also, some forms of this medicine may not be used for all of the conditions mentioned in this article.

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Your doctor may have suggested this medication for a condition that is not listed in this Medication Information article.

If you have not yet discussed this with your doctor, or if you are not sure why you are taking this medicine, consult your doctor. Do not stop taking this medicine without consulting your doctor first.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.

What forms does this medication come in?

37.5 mg

Each prolonged-release, hard gelatin capsule with gray cap and peach-colored body, imprinted “W” and “Effexor XR” on cap and number “37.5” on the body, in ink red, contains venlafaxine hydrochloride equivalent to 37.5 mg of venlafaxine base.

Nonmedicinal ingredients: microcrystalline cellulose, titanium dioxide, Opacode S-15094/45 red ink, ethylcellulose, gelatin, hydroxypropyl methylcellulose, magnetic iron oxide, and talc. Gluten-free.

75 mg

Each prolonged-release, hard gelatin capsule with peach-colored cap and body, imprinted “W” and “Effexor XR” on cap and number “75” on the body in red ink contains venlafaxine hydrochloride equivalent to 75 mg of venlafaxine base.

Nonmedicinal ingredients: microcrystalline cellulose, titanium dioxide, Opacode S-15094/45 red ink, ethylcellulose, gelatin, hydroxypropyl methylcellulose, magnetic iron oxide, and talc. Gluten-free.

150 mg

Each prolonged-release, hard gelatin capsule with a dark orange cap and body, imprinted with “W” and “Effexor XR” on the cap, and the number “150” on the body, in white ink, contains venlafaxine hydrochloride equivalent to 150 mg of venlafaxine base.

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Nonmedicinal ingredients: microcrystalline cellulose, titanium dioxide, Tek SB-0007 white ink, ethylcellulose, gelatin, hydroxypropyl methylcellulose, magnetic iron oxide, and talc. Gluten-free.

How should this medication be used?

Venlafaxine is taken once a day with food, in the morning or the evening. Swallow the capsules whole. Do not crush, bite or open the capsules.

Depression: The recommended dose of venlafaxine for people with depression is 75 mg taken once daily.

In some cases, the doctor may recommend a lower starting dose of 37.5 mg per day for the first 4-7 days of treatment to allow the person to get used to the medicine.

The dose can then be increased to 75 mg per day. If the expected benefit has not manifested after a few weeks, your doctor may gradually increase the dose until improvement is seen.

Generalized anxiety disorder (GAD): The recommended starting dose for people with a generalized anxiety disorder is 37.5 mg taken once daily for 4 to 7 days.

Your doctor may increase your dose gradually depending on your response to the medicine.

Social anxiety (social phobia): The usual recommended starting dose of venlafaxine is 75 mg taken once daily.

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In some cases, the doctor may recommend a lower starting dose of 37.5 mg per day for the first 4-7 days of treatment to allow the person to get used to the medicine.

The dose can then be increased to 75 mg per day. Your doctor may increase your dose gradually depending on your response to the medicine.

Panic disorder (panic attacks): The recommended starting dose of venlafaxine for people with panic disorder is 37.5 mg taken once daily for 7 days.

The dose can then be increased to 75 mg per day. Your doctor may increase your dose gradually depending on your response to the medicine.

Several factors can be taken into account in determining the dose a person needs: their weight, their health, and whether they are taking other medications.

If your doctor has recommended a dose other than those listed here, do not change the way you are taking the medicine without consulting your doctor.

This medicine must be taken as prescribed by your doctor. If you miss a dose, ignore the missed dose and resume your usual dosing schedule.

Do not use a double dose to make up for a missed dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.

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Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medicines in the wastewater (eg not in the sink or in the toilet bowl) or with the household garbage. Ask your pharmacist how to dispose of unused or expired medicines.

In which cases is this medication not recommended?

Do not use venlafaxine under the following circumstances:

is allergic to venlafaxine or any of the ingredients of the medication

taking an MAO inhibitor (eg phenelzine, tranylcypromine) within the last 14 days or 14 days.

What are the possible side effects of Effexor or venlafaxine

Many medications can cause side effects. A side effect is an unwanted response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medicine reported the following side effects. Many of these side effects can be managed and a few may go away on their own over time.

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Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects appear:

drowsiness;

constipation;

sexual difficulties;

a state of nervousness;

dizziness;

weakness;

unusual tiredness or weakness;

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headaches;

nausea;

loss of appetite;

abnormal dreams;

dry mouth;

sweating;

increased sweating;

sleep disturbances;

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vomitings.

Most of the side effects listed below do not happen very often, but they could cause serious problems if you do not get medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

restlessness;

mood changes or mental instability;

difficulty urinating;

severe abdominal pain;

more frequent or greater urine output;

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swelling of the hands or feet (without shortness of breath);

unusual or sudden movements of the body or face;

nervousness, an inability to sit still;

signs of liver damage (eg, yellowing of the skin and whites of the eyes, abdominal pain, dark urine, discolored stools, loss of appetite, or nausea and vomiting);

symptoms of glaucoma (increased pressure in the eyes) (eg blurred vision or decreased visual acuity, eye pain, redness of the eye, swelling of eye tissue);

symptoms of mania (eg, irritability, mood elevation, a tendency to sleeplessness, and racing thoughts);

ringing or buzzing in the ears.

Stop taking the drug and seek immediate medical attention if there is a response such as  :

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fast or irregular heartbeat

thoughts of self-harm;

convulsions;

muscle pain or weakness;

chest pain;

swelling of the hands or feet with shortness of breath;

severe headaches upon awakening that are concentrated in the back of the head and neck;

reddish or purplish patches on the skin;

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reddening, blistering, peeling, or sagging skin and mucous membranes;

signs of an allergic reaction (eg difficulty breathing, hives, swelling of the face, or swelling of the throat);

serotonin syndrome (symptoms include confusion, diarrhea, fever, poor coordination, restlessness, shivering, sweating, tremors, involuntary muscle twitching);

suicide attempts or suicidal thoughts.

Some people may experience side effects other than those listed. See your doctor if you notice any symptom that worries you while you are using this medicine.

Are there other precautions or warnings?

Before using any medication, be sure to tell your doctor about any medical conditions or allergies you may have, the medications you are using, and any other important facts about your health.

Women should mention if they are pregnant or breastfeeding. These factors could influence how you should use this medicine.

Stopping the medication: Stopping this medication suddenly may cause unwanted symptoms. If you plan to stop treatment, consult your doctor first.

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When taking venlafaxine is stopped after more than a week of treatment, it is recommended that the dose be reduced gradually to prevent symptoms such as anxiety, agitation, confusion, diarrhea, dizziness, dryness of the mind. mouth, fatigue, headache, nausea, loss of appetite, nervousness, trouble sleeping, sweating, and vomiting.

Cholesterol: Venlafaxine can raise blood cholesterol levels. If you are at risk of having high blood cholesterol or if your cholesterol level is already high before you start taking venlafaxine, talk to your doctor about how this medicine may affect your condition. influence of your condition on the administration and effectiveness of this medicine, and the relevance of specific medical supervision.

Seizures: People with a history of seizures should discuss with their doctor how this medication may affect their condition, how their condition may affect the administration and effectiveness of this medicine, and whether it is appropriate to use it. ” specific medical surveillance.

Kidney and liver function: People with impaired kidney or liver function should discuss with their doctor how this medication may affect their condition, how their condition affects the administration, and how well this medicine works. , and the relevance of specific medical surveillance.

Glaucoma: Using this medicine may worsen the symptoms of glaucoma (increased pressure in the eye).

People with glaucoma should discuss with their doctor how this medication may affect their condition, how their condition may affect the administration and effectiveness of this medicine, and the need for specific medical supervision.

While you are taking this medicine, report any changes in your vision to your doctor as soon as possible.

Heart disease: People with heart disease should discuss with their doctor how this drug may affect their condition, how their condition may affect the administration and effectiveness of this drug, and the appropriateness of monitoring. specific medical. Venlafaxine can cause an increase in blood pressure or cholesterol.

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Mania or hypomania: Venlafaxine can make mania or hypomania worse. People with a history of bipolar disorder should be kept under close medical supervision while taking this medication.

Blood pressure: Treatment with venlafaxine may raise blood pressure. Your doctor may monitor your blood pressure while you are taking venlafaxine. Rarely, some people experience a sharp rise in their blood pressure.

This extremely high blood pressure can cause rapid or irregular heartbeat, chest pain, dizziness, feeling very tired, blurred vision, and severe headaches upon waking up which are mostly localized to the back of the chest. head and neck. If any of these symptoms occur, contact your doctor immediately.

Allergic reactions: In rare cases, some people may experience an allergic reaction to this medicine. Signs of an allergic reaction include a severe rash, swelling of the face, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

Drowsiness and reduced alertness: People taking venlafaxine should not drive or operate machinery until they have known that the medicine is not interfering with their ability to perform these activities safely.

Serotonin Syndrome: This medicine can cause a rare but potentially life-threatening condition called serotonin syndrome, especially when taken together with other medicines that increase serotonin levels (eg sumatriptan, rizatriptan).

If you notice symptoms like restlessness, hallucinations, rapid heart rate, fever, lack of coordination, nausea, vomiting, and diarrhea, seek medical attention immediately.

Behavioral changes or suicidal behavior:  Some people who take this medication may experience their behavior become erratic or aggressive and experience restlessness, a depressed mood, or wanting to hurt themselves or someone else.

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If you notice any change in mood or behavior, or if your family or friends notice such changes while you are taking this medication, stop taking it and contact your doctor immediately.

Bleeding Disorders: Venlafaxine may increase the extent of bruising and lengthen the bleeding time after cuts.

People with blood disorders or with a history of blood disorders should discuss with their doctor how this medication may affect their condition, how their condition may affect the administration and effectiveness of this medicine, and how to use it. relevance of specific medical surveillance.

Pregnancy: Newborns whose mothers took medicines like venlafaxine during the third trimester of pregnancy may experience complications that require prolonged hospitalization.

These complications normally resolve over time. this medication should not be used during pregnancy unless the benefits outweigh the risks. If pregnancy occurs while you are using this medicine, contact your doctor immediately.

Breast-feeding: This medicine passes into breast milk. If you take this medicine while you are breastfeeding your baby may feel the effects. Check with your doctor to see if you should continue breastfeeding.

Children: The safety and effectiveness of this medicine have not been established for children under 18 years of age.

There have been reports that taking this drug and similar drugs by children under the age of 18 can cause behavioral and emotional changes such as suicidal thoughts and behavior.

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Can other agents interact with this medication?

There may be an interaction between venlafaxine and any of the following:

acalabrutinib;

alpha agonists (eg, clonidine, methyldopa);

alpha or beta-agonists (eg, epinephrine, norepinephrine);

rye ergot alkaloids (eg ergotamine, dihydroergotamine);

the alcohol;

amphetamines (eg, dextroamphetamine, lisdexamfetamine);

serotonin antagonists (anti-emetic drugs; eg granisetron, ondansetron);

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nonsteroidal anti-inflammatory drugs or NSAIDs (eg ibuprofen, indomethacin, naproxen);

tricyclic antidepressants (eg, amitriptyline, desipramine, imipramine);

antifungals whose name ends in “azole” (eg, itraconazole, ketoconazole, voriconazole);

antihistamines (eg, cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine);

antipsychotics (eg, chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone);

other selective serotonin-norepinephrine reuptake inhibitors (eg, desvenlafaxine, duloxetine);

barbiturates (eg, butalbital, phenobarbital);

methylene blue;

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bromocriptine;

bupropion;

buspirone;

carbamazepine;

celecoxib;

crizotinib;

cyclobenzaprine;

dasatinib;

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dexmethylphenidate;

dextromethorphan;

glucosamine;

heparin;

low molecular weight heparins (eg, dalteparin, enoxaparin, tinzaparin);

monoamine oxidase inhibitors (MAOIs; eg, moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine);

selective serotonin reuptake inhibitors (SSRIs; eg, citalopram, fluoxetine, sertraline);

grapefruit juice;

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linezolid;

lithium;

blood thinners (eg apixaban, dabigatran, edoxaban, rivaroxaban, warfarin);

antiplatelet drugs (eg acetylsalicylic acid [ASA], clopidogrel);

migraine “triptan” -type medications (eg, sumatriptan, rizatriptan, zolmitriptan);

methadone;

methylphenidate;

metoclopramide;

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St. John’s Wort;

mirtazapine;

multivitamins with minerals;

narcotic pain relievers (eg, codeine, fentanyl, morphine, oxycodone);

obinutuzumab;

pentoxifylline;

phenytoin;

primidone;

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propafenone;

pseudoephedrine;

rivaroxaban;

safinamide;

tryptophan supplements;

tramadol;

trazodone;

vitamin E.

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If you are taking any of these medicines, talk to your doctor or pharmacist. In your case, your doctor may ask you to:

stop taking any of the medications;

replace one of the drugs with another;

change the way you take one or both of the medicines.

do not change anything at all.

Interference of one medicine with another does not always mean that you stop taking one of them. Ask your doctor what to do with drug interactions.

Drugs other than those listed above may interact with this drug. Tell your doctor everything you take, whether it is prescription or over-the-counter drugs and herbal remedies.

Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine, or illegal drugs, you should tell your prescribing doctor since these substances can affect the way many drugs work.

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