Categories: Side effects

Serious side effects of lisinopril

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Discover the side effects of lisinopril.

How does lisinopril work? What are its effects?

Lisinopril belongs to the class of medications called angiotensin-converting enzyme (ACE) inhibitors.

It is used to treat high blood pressure and congestive heart failure. Side effects of lisinopril


It works by relaxing the blood vessels and helping the heart to pump the blood that carries oxygen to different parts of the body more efficiently.

It is also used immediately after a heart attack to reduce the risk of having another attack.

This medicine is available under various brand names or in different formulations, or both.


A specific brand of this medication may not be available in all forms and may not have been approved for all of the conditions discussed here.

Also, some forms of this medicine may not be used for all of the conditions mentioned in this article.

Your doctor may have suggested this medication for a condition that is not listed in this Medication Information article.

If you have not yet discussed this with your doctor, or if you are not sure why you are taking this medicine, consult your doctor.

Do not stop taking this medicine without consulting your doctor first.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.


What forms does this medication come in?

5 mg

Each pink, oval, biconvex tablet, debossed with “APO” over “L5” on one side and scoreline on the other, contains lisinopril 5 mg. Nonmedicinal ingredients: ferric oxide, orange tint, lactose, and zinc stearate.

10 mg

Each pink, oval, biconvex tablet, engraved on one side with the letter “APO” over the inscription “L10”, contains 10 mg of lisinopril. Nonmedicinal ingredients: ferric oxide, orange tint, lactose, and zinc stearate.

20 mg

Each dark pink, oval, biconvex tablet, embossed on one side “APO” over “L20”, contains 20 mg of lisinopril. Nonmedicinal ingredients: ferric oxide, orange tint, lactose, and zinc stearate.

40 mg

Each yellow, oval, biconvex tablet, engraved on one side with the letter “APO” over the inscription “40”, contains 40 mg of lisinopril. Nonmedicinal ingredients: ferric oxide, orange tint, lactose, and zinc stearate.

How should this medication be used?

The recommended adult dose of lisinopril ranges from 2.5 mg to 40 mg per day, depending on the disorder being treated. It is taken at 1 time, with or without food.

People who take other medicines to lower their blood pressure (eg diuretics) or people who have kidney disease may need lower doses.


It may take at least 2 weeks before you can see the full effect of this medicine.

The dose of lisinopril for children is determined based on their weight. Children who weigh 20 to 50 kilograms should start with 2.5 mg once a day. This dose can be gradually increased up to a daily dose of 20 mg.

Children who weigh more than 50 kilograms should start with a dose of 5 mg taken once a day. This dose can be gradually increased up to a daily dose of 40 mg.

Several factors can be taken into account in determining the dose a person needs: their weight, their health, and whether they are taking other medications.

If your doctor has recommended a dose other than those listed here, do not change the way you are taking the medicine without consulting your doctor.

It is important to use this medicine exactly as your doctor has told you. If you miss a dose, ignore the missed dose and resume your usual dosing schedule.


Do not use a double dose to make up for a missed dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medicines in the wastewater (eg not in the sink or in the toilet bowl) or with the household garbage.

Ask your pharmacist how to dispose of unused or expired medicines.

In which cases is this medication not recommended?

Do not use lisinopril under the following circumstances:

is allergic to lisinopril or any of the ingredients of the medication


are allergic to another ACE inhibitor (eg captopril, enalapril, quinapril, ramipril);

a current or potential pregnancy;

history of angioedema (a serious allergic reaction that causes swelling of the lining of the throat and tongue) after taking another ACE inhibitor (e.g. captopril, enalapril, fosinopril, ramipril).

if you have been diagnosed with hereditary angioedema ;

taking aliskiren in the presence



kidney disease;

a drug from the class of angiotensin receptor antagonists (eg irbesartan, losartan, valsartan);

another angiotensin-converting enzyme inhibitor (eg captopril, lisinopril, ramipril).

Side effects of lisinopril

Many medications can cause side effects. A side effect is an unwanted response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication.

If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.


At least 1% of people taking this medicine reported the following side effects. Many of these side effects can be managed and a few may go away on their own over time.

Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects appear:

altered taste;



changes in your sexual ability;



abdominal pain;

a runny nose;

unusual fatigue;

mild dizziness;




hair loss;

dry mouth;

signs of low blood pressure (eg dizziness, lightheadedness, or lightheadedness);

a cough (dry, persistent);

sleep disturbances.


Most of the side effects of lisinopril listed below do not happen very often, but they could cause serious problems if you do not see your doctor or receive medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

an increase in the frequency of infections or flu-like symptoms;


an itch;

chest pain;


numbness or tingling in the fingers and toes;

hallucinations (eg the illusion of hearing or seeing something that does not exist);


a rapid heartbeat;

signs of anemia (reduced number of red blood cells; e.g. dizziness, pallor, unusual tiredness or weakness, shortness of breath);

signs of depression (eg, lack of concentration, weight fluctuations, changes in sleep, disinterest in many activities, suicidal thoughts).


signs of kidney problems (eg, increased urine output at night, decreased urine output, blood in the urine, swelling, fatigue, abdominal pain);

signs of liver problems (eg, nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools );

signs of a bleeding disorder (e.g. unusual nosebleeds, bruising, blood in urine, cough with bloody sputum, bleeding gums, cuts that keep bleeding) ;

signs of excess potassium in the body (e.g. confusion, irregular heartbeat, nervousness, numbness or tingling in the hands, feet, or lips; shortness of breath or difficulty breathing; weakness or a feeling of heaviness in the legs).

Stop taking the drug and seek immediate medical attention if there is a response such as  :

signs of angioedema (eg swelling of the face, or swelling of the mouth, hands, or feet);


signs of pancreatitis (eg pain on the upper left side of the abdomen, back pain, nausea, fever, chills, fast heartbeat, swollen abdomen);

signs of a serious skin reaction (such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash with fever or discomfort);

difficulty swallowing or breathing (sudden).

Some people may experience side effects other than those listed. See your doctor if you notice any symptom that worries you while you are using this medicine.

Are there other precautions or warnings?

Before using any medication, be sure to tell your doctor about any medical conditions or allergies you may have, the medications you are using, and any other important facts about your health.

Women should mention if they are pregnant or breastfeeding. These factors could influence how you should use this medicine.


Angioedema: Taking lisinopril can cause angioedema (a serious allergic reaction that causes swelling of the face, throat, and tongue).

If you notice swelling of the face, swelling of the tongue or throat, stop taking this medicine immediately and seek medical attention immediately.

Other ACE inhibitors should not be taken in the future. People previously affected by angioedema caused by other substances now have an increased predisposition to angioedema.

Cough: People who take lisinopril may have a dry, persistent cough which usually goes away when the medicine is stopped or the dose is reduced.

Be sure to tell your doctor if you have a cough that doesn’t seem to be related to a usual cause.

Diabetes: ACE inhibitors, such as lisinopril, may lead to hypoglycemia (low blood sugar levels) in people with diabetes.


If you have diabetes, discuss with your doctor how this medication may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed. specific.

Kidney function: some people may experience changes in their kidney function (eg with narrowing of the diameter of the blood vessels or severe congestive heart failure).

The use of diuretics (pills that increase urine output), non-steroidal anti-inflammatory drugs (NSAIDs), or aliskiren may further increase the risk of kidney damage in people who are predisposed to it.

If you have reduced kidney function or if you have kidney disease, including a narrowing of the kidney blood vessels, talk to your doctor about how this medicine may affect your condition. your condition on the administration and effectiveness of this medicine, and the relevance of specific medical surveillance.

If your kidney function is poor, you may need lower doses of this medicine.

Liver function: Lisinopril may reduce liver function and cause liver failure. If you notice symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain, or swelling and itching of the skin, contact your doctor immediately.


If you have liver problems, talk to your doctor about how this medicine may affect your condition, how your condition affects the administration and effectiveness of this medicine, and whether medical supervision is needed.

Your doctor will monitor your liver function with regular blood tests while you are taking this medicine.

Low blood pressure: From time to time blood pressure may drop lower than expected after taking this medicine. This hypotension usually occurs after the first or second dose or when the dose is increased.

Your blood pressure goes down even more easily if you take diuretics (pills that increase the excretion of urine) or aliskiren if you have a reduced salt intake, if you are having dialysis, if you have diarrhea, or vomiting, or have excessive sweating and insufficient fluid intake. If the low blood pressure causes you to feel dizzy or faint, contact your doctor.

You should slowly change from lying or sitting to standing to decrease the risk of dizziness. If the low blood pressure causes you to feel dizzy or faint, contact your doctor.

Potassium levels: Some people who take this medicine experience increases in their blood potassium levels.


This rarely causes problems, but your doctor will probably want to monitor your potassium levels with blood tests.

While taking lisinopril, avoid using salt substitutes that contain potassium.

Drowsiness or reduced alertness: The use of lisinopril may cause drowsiness or dizziness, especially at the start of treatment or after a dose increase.

It may affect your ability to drive a vehicle or operate machinery. Avoid these and other dangerous activities until you know how this medicine works for you.

Pregnancy: ACE inhibitors like lisinopril can cause serious damage to the developing baby or even death if taken by the mother during pregnancy.

This medication should not be used during pregnancy. If you become pregnant while taking this medicine, stop treatment immediately and call your doctor.


Breast-feeding: This medicine passes into breast milk. If you take this medicine while you are breastfeeding your baby may feel the effects. Check with your doctor to see if you should continue breastfeeding.

Children: Neither the safety nor the effectiveness of lisinopril has been established in children less than 6 years of age. Lisinopril is not recommended for this age group. This medicine can be used by children over 6 years old to reduce high blood pressure.

Can other agents interact with this medication?

There may be an interaction between lisinopril and any of the following:

alpha agonists (eg, clonidine, methyldopa);





alpha-blockers (eg, alfuzosin, doxazosin, tamsulosin);


amphetamines (eg, dextroamphetamine, lisdexamfetamine);

diabetes medicines (eg, chlorpropamide, glipizide, glyburide, insulin, metformin, nateglinide, rosiglitazone, linagliptin, saxagliptin, sitagliptin);

nonsteroidal anti-inflammatory drugs or NSAIDs (eg ibuprofen, indomethacin, naproxen);


angiotensin II receptor blockers (eg, candesartan, losartan);


beta-blockers (eg, atenolol, propranolol, sotalol);


calcium antagonists (eg, amlodipine, diltiazem, nifedipine, verapamil);

barbiturates (eg, butalbital, pentobarbital, phenobarbital);



iron-dextran complexes;



diuretics (pills which increase urine excretion, eg furosemide, amiloride, spironolactone, triamterene);





grass pollen allergen extract;

iron gluconate;




low molecular weight heparins (e.g. dalteparin, tinzaparin)

angiotensin-converting enzyme inhibitors or ACEIs (eg, captopril, enalapril, ramipril);






isosorbide mono- and dinitrates;


phosphodiesterase-5 inhibitors (eg, sildenafil, tadalafil, vardenafil);







sodium phosphates;

substances that increase potassium levels (eg potassium chloride, salt substitutes containing potassium);








If you are taking any of these medicines, talk to your doctor or pharmacist. In your case, your doctor may ask you to:

stop taking any of the medications;


replace one of the drugs with another;

change the way you take one or both of the medicines.

do not change anything at all.

Interference of one medicine with another does not always mean that you stop taking one of them. Ask your doctor what to do with drug interactions.

Drugs other than those listed above may interact with this drug. Tell your doctor everything you take, whether it is prescription or over-the-counter drugs and herbal remedies.

Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine, or street drugs, you should tell your prescribing doctor since these substances can affect the way many drugs work


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