Categories: Side effects

Serious side effects of Gabapentin

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Below are the side effects of Gabapentin, drug interactions.

How does gabapentin work? What are its effects?

Gabapentin belongs to the class of medications called antiepileptics. It is used in combination with other drugs of the same nature for the treatment and prevention of epileptic seizures.

Gabapentin does not cure epilepsy; it only controls seizures during times when the drug is being taken. The drug works by altering the transmission of nerve signals in the brain.

This medicine is available under various brand names or in different presentations.

A specific brand of this medication may not be available in all forms and may not have been approved for all of the conditions discussed here.

Also, some forms of this medicine may not be used for all of the conditions mentioned in this article.Gabapentin side effects that you didn’t know about


Your doctor may have suggested this medication for a condition that is not listed in this Medication Information article.

If you have not yet discussed this with your doctor, or if you are not sure why you are taking this medicine, consult with your doctor.


Do not stop taking this medicine without consulting your doctor first.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.

What forms does Gabapentin come in?


100 mg

Each hard gelatin capsule, with white body and cap, imprinted “Gabapentin 100 mg” on the cap, contains 100 mg of gabapentin.

Nonmedicinal ingredients: corn starch, lactose, and talc; tunic: titanium dioxide and gelatin.

300 mg

Each hard gelatin capsule, with yellow body and cap, imprinted “Gabapentin 300 mg” on the cap, contains 300 mg of gabapentin.

Nonmedicinal ingredients: corn starch, lactose, and talc; tunic: gelatin, titanium dioxide, and yellow iron oxide.


400 mg

Each hard gelatin capsule, with orange body and cap, imprinted “Gabapentin 400 mg” on the cap, contains 400 mg of gabapentin.

Nonmedicinal ingredients: corn starch, lactose, and talc; tunic: gelatin, titanium dioxide, yellow iron oxide, and red iron oxide.


600 mg

Each white to off-white, coated, elliptical tablet, debossed with “G” over “600” on one side, contains gabapentin 600 mg.

Nonmedicinal ingredients: carnauba wax, copovidone, hydroxypropyl cellulose, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and talc.

800 mg

Each white to off-white, coated, elliptical tablet, debossed with “G” over “800” on one side and “P” on the other, contains gabapentin 800 mg.


Nonmedicinal ingredients: carnauba wax, copovidone, hydroxypropyl cellulose, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and talc.

How should we use Gabapentin?

The recommended adult dose of gabapentin is usually 300 mg taken 3 times a day initially and may increase to 600 mg taken 3 times a day as needed, as prescribed by the doctor.

The usual maximum daily dose is 2400 mg taken in 3 equal doses of 800 mg, although some people have used larger doses for a short period. Gabapentin can be taken with or without food.

Several factors can be taken into account in determining the dose a person needs: their weight, their health, and whether they are taking other medications.

If your doctor has recommended a dose other than those listed here, do not change the way you are taking the medicine without consulting your doctor.

You should not stop taking this medicine suddenly, as the seizure may come back again.  

If you think it is necessary to stop this medicine, ask your doctor to explain the timeframe to you.

This medicine must be taken exactly as your doctor has told you. If you miss a dose, take the medicine as soon as you notice the missed dose and resume treatment as soon as possible.


If your next dose is due in less than 4 hours, do not worry about the missed dose and go back to your usual dosing schedule.

To prevent seizures, take your doses at intervals of 12 hours or less.   

Do not use a double dose to make up for a missed dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medicines in the wastewater (eg not in the sink or in the toilet bowl) or with the household garbage. Ask your pharmacist how to dispose of unused or expired medicines.

In which cases is this medication not recommended?

Anyone who is allergic to gabapentin, or any of the ingredients of this medication, should not use it.

What are the possible side effects of Gabapentin

Many medications can cause side effects. A side effect is an unwanted response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent.

The side effects of Gabapentin listed below are not experienced by everyone who takes it.


If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medicine reported the following side effects. Many of these side effects can be managed and a few may go away on their own over time.

Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects appear:


•swelling of the feet or ankles;



•a cough;


•sleep disturbances.

Most of the side effects listed below do not happen very often, but they could cause serious problems if you do not see your doctor or receive medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:


•ringing in the ears;

•change in blood sugar levels and reduced control of blood sugar levels (hypoglycemia – cold sweats, paleness, and freshness of the skin, headache, fast heart rate, weakness; hyperglycemia – frequent urination, increased thirst, and hunger, unexplained weight loss, poor healing of wounds, infections, acetone odor in the breath);

•unusual mood swings;



•unexplained muscle pain or tenderness, muscle weakness, dark urine with nausea or vomiting;

•chest pain;

•hallucinations (eg the illusion of hearing or seeing something that does not exist);

•an inability to control urination; fast heart rate or very pounding heartbeat (palpitations);

•poor coordination;

•signs of depression (eg, lack of concentration, weight fluctuations, changes in sleep, disinterest in many activities, suicidal thoughts);

•symptoms of low sodium level in the blood (eg, fatigue, weakness, confusion, sore, stiff or uncoordinated muscles);

•symptoms of liver problems (eg abdominal pain, persistent vomiting, feeling unwell, fever, itching, yellowing of the skin and whites of the eyes, dark urine).


•Stop taking the drug and seek immediate medical attention if there is a response such as:

•worsening of seizures;

thoughts suggesting that you hurt yourself or other people.

•loss of consciousness;

•slow, shallow, or weak breathing;

signs of a serious skin reaction (such as blistering, peeling, rash covering a large area of the body, rash that spreads quickly, or rash with fever or discomfort).

signs of a serious allergic reaction (eg swelling of the face or swelling of the throat, hives, or difficulty breathing).

Some people may experience side effects other than those listed. See your doctor if you notice any symptom that worries you while you are using this medicine.


Are there other precautions or warnings?

Before using any medication, be sure to tell your doctor about any medical conditions or allergies you may have, the medications you are using, and any other important facts about your health.


Women should mention if they are pregnant or breastfeeding. These factors could influence how you should use this medicine.

Alcohol and other drugs that cause drowsiness:

People taking this drug should not combine it with alcohol and should avoid combining it with other drugs that cause drowsiness such as narcotic pain relievers.

Otherwise, it can cause additive drowsiness and reduced breathing effect as well as an increased risk of opioid overdose which can be dangerous and possibly fatal.

Stopping the drug: Suddenly stopping gabapentin, along with other medicines used to manage seizures, may increase the risk of seizures.

Do not suddenly stop taking gabapentin. Ask your doctor how it is best to safely and gradually stop taking the medicine.

Suicidal or agitated behavior:

People taking this medication may experience restlessness (impatience, anxiety, aggression, strong emotions, and a feeling of not being themselves), or they may want to hurt or hurt someone.

If you experience these side effects, or if you think they affect a family member who is using this medicine, contact your doctor immediately.


While you are taking this medicine, your doctor should monitor you closely for emotional and behavioral changes.

Difficulty breathing:

Gabapentin can cause serious breathing problems that could be life-threatening.

If you have breathing or lung problems, if you have reduced kidney function, if you are taking medicines that may slow your breathing, or if you are over 65 years of age, your risk of having difficulty breathing is increased.

If your breathing slows down or you notice difficulty in breathing, seek medical attention immediately.

Kidney function:

Kidney disease or reduced kidney function can cause this drug to build up in the body, causing side effects.

If you have reduced kidney function or have kidney disease, talk to your doctor about how this medicine may affect your condition, how your condition affects the way it is given, and how well it works. the drug, and the relevance of specific medical surveillance.

Drowsiness or reduced alertness:

If you have uncontrolled epilepsy, you should avoid driving or operating potentially dangerous machinery.

Gabapentin may cause drowsiness, dizziness, or poor coordination. Avoid performing tasks that require alertness or coordination until you have determined the effect of this drug on your mental reaction skills.


Hypersensitivity syndrome:

A few people have experienced a serious allergic reaction called hypersensitivity syndrome when they have been treated with gabapentin.

Stop taking the drug and seek immediate medical attention if you have symptoms of a severe allergic reaction, including fever, enlarged lymph nodes, yellowing of the skin or whites of the eyes, symptoms of the flu. such as rashes or blisters.


Gabapentin crosses the placenta and can harm a developing baby if taken by the mother during pregnancy.

This medication should not be used during pregnancy unless the benefits outweigh the risks.

If pregnancy occurs while you are using this medicine, contact your doctor immediately.


This medicine passes into breast milk. If you use gabapentin while you are breastfeeding your baby may feel the effects. Check with your doctor to see if you should continue breastfeeding.


The safety and effectiveness of this medicine have not been established in children.


Seniors are predisposed to side effects and may require a reduction in the dose of this medication due to reduced kidney function.


Can other agents interact with this medication?

There may be an interaction between gabapentin and any of the following:


•general anesthetics (medicines used to induce deep sleep before surgery);

•antacids containing magnesium or aluminum;

•tricyclic antidepressants (eg, amitriptyline, imipramine);

•antihistamines (eg, cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine);

•antipsychotics (eg, chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone);

•other anti-epileptic drugs (eg, carbamazepine, clobazam, ethosuximide, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide);



•benzodiazepines (eg alprazolam, diazepam, lorazepam);

•sodium bicarbonate;





•calcium carbonate;


•sodium oxybate;



•chloral hydrate;

•selective serotonin reuptake inhibitors (SSRIs; eg, citalopram, fluoxetine, paroxetine, sertraline);






•narcotic pain relievers (eg, codeine, hydrocodone, morphine, oxycodone);




•muscle relaxants (eg, baclofen, cyclobenzaprine, methocarbamol, orphenadrine);














If you are taking any of these medicines, talk to your doctor or pharmacist. In your case, your doctor may ask you to:

•stop taking any of the medications;

•replace one of the drugs with another;

•change the way you take one or both of the medicines.

do not change anything at all.

Interference of one medicine with another does not always mean that you stop taking one of them. Ask your doctor what to do with drug interactions.

Drugs other than those listed above may interact with this drug. Tell your doctor everything you take, whether it is prescription or over-the-counter drugs and herbal remedies.


Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine, or illegal drugs, you should tell your prescribing doctor since these substances can affect the way many drugs work.


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