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Contraindications and side effects of viloxazine

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Discover the contraindications and side effects of Viloxazine.

This antidepressant has been on the market for years but is no longer sold for its harmful effects.

This antidepressant was withdrawn from the market due to its possible damaging effects on the brainContraindications and side effects of Viloxazine

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The creation of new drugs to combat all kinds of diseases and disorders, both psychological and physical, is a dynamic process in which any drug can be withdrawn from the market almost as quickly as it was put on it.

Either for economic reasons or the benefits of the company, such as for security reasons.

This is the case with viloxazine, an antidepressant marketed for just over twenty years and which we will talk about throughout this article.

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In the same way, we will analyze its uses and its form of administration, as well as its possible side effects and the precautions that those who consumed it should take.

What is viloxazine?

Viloxacin, known commercially by the names of Vivalan, Emovit, Vivarint, and Vicilan, was an antidepressant drug whose main active ingredient was a derivative of morpholine and which was categorized within the group of selective norepinephrine reuptake inhibitors (ISRN).

This drug was discovered and launched on the market in 1976. During its commercialization period, it was used as an antidepressant in a large number of European countries, becoming quite famous due to its stimulating effects similar to those of amphetamines, but without the effects so addictive or without the signs of dependence on these.

Although it was never approved by the American Food and Drug Administration (FDA), it was granted a designation for the treatment of narcolepsy and cataplexy. However, it was withdrawn from markets around the world in 2002, citing commercial reasons.

Regarding its form of action as an antidepressant, it was observed that, in animal models, viloxazine inhibits the reuptake of norepinephrine in the hearts of rats and mice.

Regarding the inhibition of serotonin reuptake, this drug enhanced the brain functions mediated by this neurotransmitter in the same way as other more powerful antidepressants such as amitriptyline or imipramine; also showing no anticholinergic effect.

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Finally, it was also discovered that, in rats, it very effectively regulates the GABAergic receptors in the frontal cortex of these animals.

In what cases was this antidepressant used?

Viloxazine was administered, in some European countries, as the drug of choice for the treatment of depression or major depressive disorder.

Depression or major depressive disorder is a mental or psychological condition characterized by the fact that the person who suffers from it experiences a constant and acute feeling of negative emotions such as sadness and anguish.

Depression is often accompanied by low self-esteem, loss of interest in activities that were usually pleasant or attractive, decreased energy, and pain for no apparent reason.

While in milder cases, depression can appear intermittently, alternating periods of depression and periods of emotional stability. While in the most serious the person has the symptoms permanently; including faulty beliefs or even visual or auditory hallucinations.

Major depressive disorder can significantly and negatively interfere with the day-to-day life of the patient; modifying your routines, your eating habits, your sleep cycles, and your general health.

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The decline of the person can become so serious that between 2 and 7% of people with depression resort to suicide as a way to eliminate the suffering suffered.

How was it administered?

Viloxazine was marketed as tablets for oral administration. Usually, it was recommended to ingest daily doses of between 50 and 100 milligrams, once every 8 or 12 hours and, if possible, accompanied by some food.

In addition, the last dose had to be ingested, recommended, before 6 in the afternoon.

However, in the most severe cases, the dose could be increased to 400 milligrams of viloxazine per day.

It is necessary to specify that, neither in this case nor in that of any other medicine, the patient should alter the doses indicated by the medical professional on their own, since these are adjusted to the needs or condition of the patient.

Otherwise, there is the possibility that the patient will experience serious side effects such as sudden changes in mood, among many other symptoms.

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Due to the way viloxazine works, in most cases the pharmacological treatment began gradually, starting with lower doses which increase as the first weeks of treatment elapse.

In addition, viloxazine should never be withdrawn abruptly, since the side effects of this interruption in the consumption of the drug could cause withdrawal symptoms such as severe headaches, increased muscle stiffness, mood changes, dizziness, or dizziness

Side effects of viloxazine

As with the vast majority of psychiatric medications, viloxazine also had several side effects that, although not always significant or serious, did appear quite frequently.

In most cases, the appearance of side effects was due to a delay in the pharmacological action of the medication and mainly affected the central and autonomic nervous systems.

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These adverse reactions could be divided into frequent side effects that appear between 10 and 25% of cases), occasional (between 1 and 9% of cases), and rare side effects (less than 1% of cases).

1. Frequent side effects

Sickness. Vomiting. Headache.

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2. Occasional side effects

These are somewhat rarer side effects of ofloxacin.

•Constipation.

•Dry mouth

•Urinary retentions.

•Tachycardias.

•Accommodation disorders.

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3. Rare side effects

In these rare but serious cases, viloxazine treatment had to be stopped immediately and always under the supervision and supervision of a doctor.

•Cardiac arrhythmias.

•Orthostatic hypotension.

•Worsening of anxiety.

•Agitation.

•Drowsiness or insomnia

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•Ataxia.

•Confusion.

•Tremors.

•Paresthesia.

•Sweating

•Myalgia.

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•Mild hypertension.

•Rashes.

•Convulsions.

•Jaundice.

What precautions should be taken during its consumption?

Before starting treatment, the patient had to inform his doctor of any special health condition in which he found himself, especially if it included cardiovascular disorders, epilepsies, liver failure, or kidney failure.

In the same way, several medications could interfere with the action of viloxazine. These included antiepileptic drugs, levodopa, theophylline, or St. John’s wort.

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Despite no adverse effects of the consumption of viloxazine during pregnancy, it could be excreted in breast milk, so it was common to recommend not administering this drug during the last weeks of pregnancy and breastfeeding.

Finally, like other antidepressant drugs, viloxazine could cause states of drowsiness and confusion, so driving vehicles and operating heavy machinery were discouraged during treatment.

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Published by
lbobvalla
Tags: contraindications contraindications of Viloxazine dangers disadvantages health side effects side effects of Viloxazine uses

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