Discover the 9 benefits of Cannabidiol CBD for pain and mental health.
Only recently, marijuana and chemically related compounds have again been considered of therapeutic value.
A prominent compound found in marijuana or cannabis, CBD, or cannabidiol , has been shown to treat numerous diseases.
Researchers believe that in view of CBD’s very low toxicity and generally benign side effects, neglecting or denying the benefits of cannabidiol and its clinical potential is simply unacceptable.
The use of medical marijuana remains an emotionally and politically charged topic.
Although cannabis oil preparations have been used in medicine for millennia, concern about the dangers of abuse led to the prohibition of the medicinal use of marijuana in the 1930s.
CBD is one of more than 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids.
Until recently, THC (tetrahydrocannabinol) received most of the attention because it is the ingredient in cannabis that produces mind-altering effects in consumers, but CBD is also present in high concentrations, and the world of medicine you are finding that your list of medical benefits continues to grow.
Cannabidiol is the main non-psychoactive component of Cannabis sativa. According to a 2013 study published in the British Journal of Clinical Pharmacology, the benefits of CBD include acting in some experimental models as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent, and therefore is a potential drug for treatment of neuroinflammation, epilepsy, oxidative lesions, vomiting and nausea, anxiety and schizophrenia.
Research is beginning to show that CBD is different from other well-studied cannabinoids. All cannabinoids act as ligands, which means that they adhere to the binding site of a protein and have the ability to modulate the behavior of a receptor.
CB1 receptors are widely distributed, but are particularly abundant in areas of the brain, including those related to movement, coordination, pain and sensory perception, emotion, memory, cognition, and autonomic and endocrine functions.
CB2 receptors are found primarily in the immune system and appear to reduce inflammation and certain types of pain.
Although all cannabinoids have similar structures, they show a wide range of actions at each of the different receptors.
However, scientists are finding that CBD has very little effect on the CB1 and CB2 receptors, which probably explains why it has no mind-altering effects, unlike THC, which positively regulates the CB1 receptor.
This is why most recreationally grown marijuana is typically very low in CBD and high in THC.
• Among the common benefits of cannabidiol, natural pain relief tops the list for many.
• Evidence indicates that cannabinoids may be helpful in modulating pain by inhibiting neural transmission in pain pathways.
• A 2012 study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing tolerance to pain relievers.
• The researchers suggest that CBD and other non-psychoactive components of marijuana could represent a new class of therapeutic agents for the treatment of chronic pain.
• According to a meta-analysis conducted in Canada in 2007, the combination of CBD and THC mouth spray was found to be effective in treating neuropathic pain in multiple sclerosis, which can be debilitating for 50 to 70 percent of MS patients.
• Research shows that cannabidiol benefits include producing antipsychotic effects.
• It appears to have a pharmacological profile similar to that of atypical antipsychotic drugs observed by behavioral and neurochemical techniques in animal studies.
• Furthermore, studies show that CBD prevents experimental psychosis in humans and is effective in open case reports and clinical trials in patients with schizophrenia, with a remarkable safety profile.
• Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic effect of cannabidiol.
• Cannabidiol has been shown to reduce anxiety in patients with social anxiety disorder, and researchers suggest that it may also be effective for panic disorder, obsessive compulsive disorder, social anxiety disorder, and post-traumatic stress disorder.
• A 2011 study aimed to compare the effects of a sham speaking test in healthy control patients and native-born social anxiety disorder treatment patients.
• A total of 24 treatment-naïve patients with social anxiety disorder were administered CBD or placebo 1.5 hours prior to testing.
• The researchers found that pretreatment with CBD significantly reduced anxiety, cognitive impairment, and discomfort in speaking performance, and significantly reduced alertness in anticipation of speech.
• The placebo group presented greater anxiety, cognitive impairment and discomfort.
• Several scientific reports show that the benefits of cannabidiol include the possession of antiproliferative and pro-apoptotic effects that inhibit the migration, adhesion and invasion of cancer cells.
• A study published in 2006 in the Journal of Experimental Pharmacology and Therapeutics found for the first time that CBD potently and selectively inhibited the growth of different breast tumor cell lines and exhibited significantly less potency in non-cancer cells.
• In 2011, researchers added light on the cellular mechanism through which cannabidiol induces cell death in breast cancer cells.
• They demonstrated that cannabidiol induced concentration-dependent cell death of both estrogen receptor-positive cells and estrogen receptor-negative breast cancer cells.
• They also found that effective concentrations of CBD in tumor cells have little effect on non-tumor breast cells.
• CBD behaves as a non-toxic compound and studies show that doses of 700 milligrams per day for 6 weeks did not show any overt toxicity in humans, suggesting that it can be used for long-term treatment.
• Research not only shows that CBD benefits include being effective in fighting breast cancer cells, the data also suggests that it can be used to inhibit the invasion of lung and colon cancer, as well as possessing properties antitumor agents in gliomas and has been used to treat leukemia.
• Cannabis has been used for centuries to suppress nausea and vomiting.
• Research has revealed that among more than 80 cannabinoid compounds found in marijuana, both the intoxicating THC and the non-intoxicating CBD help eliminate nausea and vomiting in animal studies.
• A 2012 study published in the British Journal of Pharmacology found that CBD benefits include possessing anti-nausea and anti-emetic effects when administered to rats.
• The researchers found that cannabidiol acts diphasic, meaning that at low doses it suppresses toxin-induced vomiting, but at high doses it increases nausea or has no effect.
• A 2014 survey by Stanford University researchers was presented to parents who belong to a Facebook group dedicated to sharing information about using cannabidiol-enriched cannabis to treat their children’s seizures.
• Nineteen responses met the inclusion criteria for the study: a diagnosis of epilepsy and current use of CBD-enriched cannabis.
• The CBD average number of antiepileptic drugs tested before using cannabis was 12.
• Sixteen (84 percent) of the 19 parents reported a reduction in their children’s seizure frequency while taking CBD cannabis.
• Of these, two (11 percent) reported complete seizure freedom, eight (42 percent) reported a greater than 80 percent reduction in seizure frequency, and six (32 percent) reported a 25-percent reduction in seizure frequency. 60 percent in seizures.
• Other beneficial effects included increased alertness, better mood, and better sleep; while side effects included drowsiness and fatigue.
• Later in 2014, researchers reported preliminary results of a study involving children with treatment-resistant epilepsies in an expanded access “compassionate use program.”
• The patients received a 98 percent oil-based purified CBD extract called Epidiolex, which is manufactured by GW Pharmaceuticals.
• After three months of treatment, 39 percent of the 23 patients had a more than 50 percent reduction in seizures, with an average reduction of 32 percent.
• These preliminary results support animal studies and survey reports that CBD may be a promising treatment for refractory epilepsy and is generally well tolerated at doses up to 25 milligrams per kilogram of body weight.
• A 2006 study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an 86 percent incidence in untreated mice to a 30 percent incidence in CBD-treated mice.
• CBD benefits also showed a significant reduction in plasma levels of pro-inflammatory cytokines.
• A histological examination of the pancreatic islets of the CBD-treated mice revealed a significant reduction in insulitis.
• In 2013, the American Journal of Medicine published a study that highlighted the impact of marijuana use on glucose, insulin, and insulin resistance among American adults.
• The study included 4,657 adult men and women from the National Health and Nutrition Survey from 2005 to 2010.
• Of the participants, 579 were current marijuana users and 1,975 were former users.
• The researchers found that current marijuana use was associated with a 16 percent reduction in fasting insulin levels.
• They also found significant associations between marijuana use and smaller waist circumferences, a factor related to the onset of diabetes symptoms.
• A 2013 study published in the British Journal of Clinical Pharmacology reports that CBD protects against vascular damage caused by high glucose in the environment, inflammation, or the induction of type 2 diabetes in animal models.
In addition, CBD has been shown to reduce vascular hyperpermeability (which causes intestinal leakage) associated with such environments.
CBD and THC are the two main compounds in the marijuana plant and they are the only two cannabinoids that have been well characterized to date.
Many strains of marijuana are known to have high levels of THC and high strains of CBD are less common.
However, the medical community is paying more attention to the therapeutic effects of CBD, which is beginning to change.
Both compounds have significant health benefits: THC has antispasmodic, analgesic, antispasmodic, anti-tremor, anti-inflammatory, appetite-stimulating, and antiemetic properties, and CBD has anti-inflammatory, anticonvulsant, antipsychotic, antioxidant, neuroprotective, and immunomodulatory effects.
The clinical use of THC is often limited by its unwanted psychoactive side effects, and for this reason, interest in non-psychoactive phytocannabinoids, such as CBD, has increased substantially in recent years.
Another important difference between THC and CBD is that marijuana with high levels of THC is commonly used for its sleep-inducing effects, while CBD appears to promote wakefulness.
At the federal level, CBD is classified as a Schedule 1 drug in the United States because it is one of the many cannabinoids present in marijuana.
Being labeled as a Schedule 1 drug means that it has a high potential for abuse and to create severe psychological or physical dependence; therefore, the use of these drugs for medical use is not allowed.
Medical research can and is being conducted on Schedule 1 substances, including CBD and other active ingredients in marijuana, but there are strict regulations and administrative hurdles associated with this status.
According to the Federation of American Societies for Experimental Biology, the DEA is currently conducting a scientific review of the CBD to elucidate its pharmacology and liability for abuse and to identify gaps in the published literature. .
In 1996, California voters passed Proposition 215, allowing the use of medical marijuana. Since then, 27 more states, in addition to the District of Columbia, Guam and Puerto Rico, have enacted similar laws allowing comprehensive public medical marijuana and cannabis programs.
More recently, 17 states have approved the use of low-THC, high-CBD pbut roducts for medical reasons in limited situations.
Each state has specific requirements and conditions that must be followed to legally use the CBD, such as patient registration requirements and product definitions that are allowed.
The 17 states that allow limited access to low-THC and high-CBD marijuana products include:
• North Carolina
• South Carolina
• Idaho (vetoed by the governor in 2015)
Although the research on the medicinal use of cannabis is intense, several studies indicate that the recreational use of cannabis can have persistent adverse effects on mental health.
According to a 2013 report published in Frontiers of Psychiatry, depending on the frequency with which it is used, the age of onset, the potency of the cannabis used and the individual sensitivity of the person, recreational cannabis use can cause disorders. permanent psychological
Most recreational users will never face such a persistent mental illness, but in some individuals, cannabis use produces undesirable effects, such as cognitive impairment, anxiety, paranoia, and an increased risk of developing chronic psychosis or drug addiction.
Some studies show that CBD can counteract these adverse effects, but more research is needed as most of this research is done on animals or based on anecdotal reports.
Little research has focused on the safety and side effects of CBD in humans; however, clinical trials indicate that only a few, usually mild, side effects have been observed after CBD administration and tolerance to CBD does not appear to occur.
• CBD is one of more than 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids; It is the main non-psychoactive component of Cannabis sativa.
• Many strains of marijuana are known to have high levels of THC and high strains of CBD are less common; However, the medical community is paying more attention to the therapeutic effects of CBD, which is beginning to change.
• 17 states have approved the use of low-THC, high-CBD products for medical reasons in limited situations.
• Each state has specific requirements and conditions that must be followed to legally use the CBD, such as patient registration requirements and product definitions that are allowed.
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